It is an epidemiology study to explore outcomes in patients with acute kidney injury (AKI) and sepsis submitted to continuous renal replacement therapy (CRRT) with Oxiris™. Objectives: Describe the experience and outcomes in patients with sepsis and AKI treated receiving CRRT with the adsorption membrane filter Oxiris™
Study Background \& Rationale: Acute kidney injury (AKI) is common in patients with sepsis, occurring in 5-50%. It happens in the context of a critical illness requiring intensive care. Fifteen percent require renal replacement therapy as supportive therapy until the kidneys recover. Membrane-coated filters, such as Oxiris™, promote high filtration clearance of uremic toxins, but additionally removal of inflammatory mediators and bacterial liposaccharide (LPS) . Even though this potential mechanism should be expected to benefit septic and AKI patients, results have not been uniform. The investigators´ group has been prescribing CRRT for AKI treatment for the last 20 years, having performed more than 20 thousand procedures. The investigators´ group experience with Oxiris™ filter in CRRT started in 2018. The objective of the study is to describe the clinical operational management of CRRT with this kind of filter and to explore patients' outcomes.
Study Type
OBSERVATIONAL
Enrollment
50
Continuous Renal Replacement Therapy with the adsorption membrane filter Oxiris™
Nefro Consultoria de Doenças Renais
Rio de Janeiro, Brazil
Mortality observed and estimated by predictive indexes
In-hospital mortality observed and estimated by the predictive index (SAPS III) during the hospitalization which developed AKI and need CRRT with Oxiris
Time frame: Through study completion, an average of 5 years
Management of hemodynamic drugs during CRRT
Daily dosage of hemodynamic active drugs (mg/day) during the hospitalization which developed AKI and need CRRT with Oxiris
Time frame: Through study completion, an average of 5 years
Hemorrhagic complications during CRRT
Occurrence of hemorrhagic events during the hospitalization which developed AKI and need CRRT with Oxiris
Time frame: Through study completion, an average of 5 years
CRRT circuit life-time
Days of CRRT circuit with Oxiris utilization, during the hospitalization which developed AKI and need CRRT with Oxiris
Time frame: Through study completion, an average of 5 years
CRRT dependence
Time in days on CRRT need, during the hospitalization which developed AKI and need CRRT with Oxiris
Time frame: Through study completion, an average of 5 years
Initial renal function recovery
Time in days to urinary debt \>1L/day, during the hospitalization which developed AKI and need CRRT with Oxiris
Time frame: Through study completion, an average of 5 years
Length of hospital stay
Length of hospital stay in days of hospitalization which developed AKI and need CRRT with Oxiris
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Time frame: Through study completion, an average of 5 years
Renal function recovery in medium term
Renal function by creatinine levels (mg/dl) at 30 days after hospital admission of the hospitalization which developed AKI and need CRRT with Oxiris
Time frame: At 30 days after hospital admission in which participants developed AKI
Renal function recovery at discharge
Renal function by creatinine levels (mg/dl) at discharge of the hospitalization which developed AKI and need CRRT with Oxiris
Time frame: Through study completion, an average of 5 years
Dialysis dependence in long term
Dialysis dependence at discharge of the hospitalization which developed AKI and need CRRT with Oxiris
Time frame: Through study completion, an average of 5 years