The objective of this trial is to evaluate the effect of the consumption of a mixture of extracts and DHA on the mild cognitive impairment.
According to the World Health Organization, around 50 million people in the world have dementia, so developing new strategies to prevent cognitive impairment is an important aspect. Certain plant extracts have properties related to the improvement of brain function. In addition, adequate levels of DHA are essential for good cognitive functioning throughout the life cycle. Therefore, the objective of this trial is to evaluate the effect of the consumption of a mixture of extracts and DHA on the mild cognitive impairment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
110
Each participant will consume 1 dissolving powder pack per day diluted in water, with breakfast, without any restriction in the diet or in their life habits.
Each participant will consume 1 dissolving powder pack per day diluted in water, with breakfast, without any restriction in the diet or in their life habits.
Complejo hospitalario Ruber Juan Bravo. Servicio de Neurología y Neurofisiología
Madrid, Madrid, Spain
Score of the Delayed Memory test.
Wechsler Memory Scale III questionnaire, delayed recall
Time frame: 6 months
Score of the Mini Mental State Examination test.
Total score obtained in tests of: orientation, fixation, calculation and attention, memory, language and construction.
Time frame: 6 months
Score of the Immediate Memory test.
Wechsler Memory Scale III questionnaire, immediate recall.
Time frame: 6 months
Total score of the ADAS-cog neurocognitive test.
Total score obtained in tests of: word recall, commands, object and finger naming, constructive praxis, ideational praxis, orientation, word recognition, memory test instruction recall, spoken language ability, spoken language comprehension, difficulty finding the right words.
Time frame: 6 months
Analysis of plasma levels of interleukins IL-6 to inflammatory parameters.
Levels of interleukins IL-6
Time frame: 6 months
Analysis of plasma levels of interleukins IL-2 to inflammatory parameters.
Levels of interleukins IL-2
Time frame: 6 months
Analysis of plasma levels of interleukins IL-10 to inflammatory parameters.
Levels of interleukins IL-10
Time frame: 6 months
Analysis of plasma levels of PTX3 to inflammatory parameters.
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Levels of PTX3
Time frame: 6 months
Analysis of plasma levels of SAP to inflammatory parameters.
Levels of SAP.
Time frame: 6 months
Analysis of plasma levels of glucose related to glucose metabolism.
Levels of glucose
Time frame: 6 months
Analysis of plasma levels of insulin related to glucose metabolism.
Levels of insulin
Time frame: 6 months
Index of the HOMA IR
Index of the HOMA IR
Time frame: 6 months