Impact of Protamine Dose Reduction on Platelet Aggregation After Extracorporeal Circulation for Minimally Invasive Aortic Valve Replacement Surgery

N/ANot Yet RecruitingNCT06254404

University of Liege50 enrolled

Overview

Determining the minimum effective dose of protamine after extracorporeal circulation for mini-sternotomy aortic valve replacement surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Protamine Dose Protamine Adverse Reaction

Interventions

Low dose protamineDRUG

Administration of 70% of the normal dose of protamine

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Mini-sternotomy aortic valve replacement surgery * Major patients Exclusion Criteria: * Hypersensitivity to protamine * Coagulation Abnormalities * Heparin allergy * Pregnant women * Jehovah's Witnesses

Outcomes

Primary Outcomes

Minimum effective dose of protamine after extracorporeal circulation. A bottom-up and top-down method will define CP 50.

Time frame: 24 hours

Central Contacts

Benjamin Javillier, MD

CONTACT

43667180 javillier.benjamin@hotmail.com

Data from ClinicalTrials.gov

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