The goal of this study is to show that trained detection dogs can identify breast, lung, prostate or colorectal cancer by sniffing masks containing breath samples. In this study, individuals who will undergo cancer screening at an integrated cancer prevention center or biopsy for a suspected malignancy, will be asked to provide a breath sample by breathing into a surgical mask. The mask will then be sent to the laboratory, where trained detection dogs will determine if the person who provided the mask has breast, lung, prostate or colorectal cancer or if the person does not have these types of cancer. The results provided by the dogs will be compared to the actual cancer screening results or biopsy results in order to determine the accuracy of cancer detection by the trained dogs.
Study Type
OBSERVATIONAL
Enrollment
1,250
Rambam Health Care Campus
Haifa, Israel
RECRUITINGTel Aviv Sourasky Medical Center
Tel Aviv, Israel
RECRUITINGSpecificity of detection of any cancer (breast, lung, prostate or colorectal cancer) by the breath test.
Specificity is defined as the number of participants who were identified by the breath sample test as negative for cancer divided by the number of participants who were identified by the gold standard test as being negative for cancer.
Time frame: 2 years
Sensitivity of detection of any cancer (breast, lung, prostate or colorectal cancer) by the breath test.
Sensitivity is defined as the number of participants who were identified by the breath sample test as positive for cancer divided by the number of participants who were identified by the gold standard test as being positive for cancer.
Time frame: 2 years
Specificity, sensitivity, negative predictive value, and positive predictive value of the breath test for detecting breast cancer
Time frame: 2 years
Specificity, sensitivity, negative predictive value, and positive predictive value of the breath test for detecting colorectal cancer
Time frame: 2 years
Specificity, sensitivity, negative predictive value, and positive predictive value of the breath test for detecting lung cancer
Time frame: 2 years
Specificity, sensitivity, negative predictive value, and positive predictive value of the breath test for detecting prostate cancer
Time frame: 2 years
The rate of early-stage cancer cases detected by the breath test
Time frame: 2 years
Inter-observer variability among the detection dogs
Time frame: 2 years
Intra-observer variability among the detection dogs
Time frame: 2 years
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