The differential and systematic diagnosis of malaria, dengue and chikungunya in patients with fever (≥38.5°C) of undetermined etiology would allow the identification of infection by these pathogens and thus limit the inappropriate use of antibiotics (discontinuation or non-initiation) and optimize the clinical management and prognosis of patients.
The research hypotheses are as follows: * Systematic diagnosis of malaria, dengue and chikungunya using diagnostic tests would improve the clinical management of patients with fever of undetermined etiology and reduce the misuse of antibiotics (discontinuation or non-initiation) and associated resistance. * Improved management is associated with a reduction in the use of hospital resources, professional inactivity and an improvement in the quality of life and satisfaction of patients.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
804
For patients managed in an "intervention site", a diagnostic test for dengue and chikungunya using VIDAS® as well as a screening test for malaria will be carried out. An awareness campaign on the use of VIDAS® diagnostic tests will be implemented as well. The diagnosis will be based on the patient's clinical symptoms, the biological results of the VIDAS® tests for dengue and chikungunya, as well as the results of the tests for malaria.
For patients managed in a "control site", the standard of care practices will be applied in the case of a febrile condition of undetermined etiology. This includes clinical diagnosis and, where appropriate, the use of routinely available diagnostic tests. At the end of the study, the collected samples will be tested using VIDAS® differential diagnosis tests to estimate the number of cases of dengue and chikungunya that have not been correctly diagnosed.
Institut de Recherche en Sciences de la Santé
Ouagadougou, Burkina Faso
CHU Cocody
Abidjan, Cocody, Côte d’Ivoire
CHU Treichville
Abidjan, Treichville, Côte d’Ivoire
Rate of antibiotic prescription
Rate of antibiotic prescription (discontinuation or non-initiation).
Time frame: Inclusion and Day 7
Consumption of hospital resources
Number of days in hospital.
Time frame: Day 7
Consumption of hospital resources
Number of hospital visits within 7 days.
Time frame: Day 7
Patient satisfaction
Patient satisfaction with the health care (measured on a scale of 1 (worse) to 5 (better)).
Time frame: Inclusion and Day 7
Patient's quality of life
Percentage on patient's quality of life (1 (worse) to 100 (better)) + EQ-5D questionnaire.
Time frame: Inclusion and Day 7
Patient's loss of productivity
Questionnaire on number of working day lost.
Time frame: Inclusion and Day 7
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