The current project was designed to examine the effects of BCAA metabolic dysfunction on cardiac function in septic patients.
Patients with sepsis and with/without type 2 diabetes will be included. Patients prospectively collected the following indicators in the intensive care unit: 1. myocardial injury-related biomarkers: troponin T and B natriuretic peptide levels; 2. cardiac structure-related indicators: the size of the left and right ventricle, left ventricular ejection fraction, etc.3. septic cardiomyopathy incidence: Troponin T\>0.01ng/ml is the standard for the diagnosis of septic cardiomyopathy. Additionally, the investigators will collect the peripheral blood at preoperative, day 1, day 3, and day 5 after surgery. Peripheral blood plasma and PBMCs were separated by differential centrifugation: the concentration of BCAAs in serum and PBMCs; the expression of PBMCs BCAAs metabolic enzymes BCAT 1, BCKDH, and PP 2 Cm by WB; and the levels of AST, ALT, LDH, CK, and CK-MB
Study Type
OBSERVATIONAL
Enrollment
50
Effect of BCAAs metabolic dysfunction on cardiac function in sepsis
The incidence of Sepsis induced cardiomyopathy
Diagnostic criteria for Sepsis induced cardiomyopathy, TroponinT \> 0.01 ng/ml
Time frame: up to 7 days post-ICU admission, or at hospital discharge, whichever comes first
Plasma levels of TroponinT
If multiple measurements is available during the first 7 days, the mean measurement will be used for analysis.
Time frame: up to 7 days post-ICU admission, or at hospital discharge, whichever comes first
Plasma levels of type B natriuretic peptide
If multiple measurements is available during the first 7 days, the mean measurement will be used for analysis.
Time frame: up to 7 days post-ICU admission, or at hospital discharge, whichever comes first
ejection fraction
If multiple measurements is available during the first 7 day, the mean measurement will be used for analysis.
Time frame: up to 7 days post-ICU admission, or at hospital discharge, whichever comes first
Left ventricular and right ventricular size
If multiple measurements is available during the first 7 day, the mean measurement will be used for analysis.
Time frame: up to 7 days post-ICU admission, or at hospital discharge, whichever comes first
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.