The goal of this randomized controlled trial is to test the effect of time-restricted eating (14-hour fast, 10-hour eating window) of a low-energy dense diet (reduced calories per gram of food) in older adults with obesity and insulin resistance. The study aims to determine if modulating the energy density of the diet reduces: 1. Insulin resistance and 2. Body weight. Researchers will compare the groups: 1. Following time-restricted eating and given a diet reduced in energy density or 2. Following time-restricted eating and given a diet typically consumed in this population
The study is an eight-week randomized controlled double-blinded clinical trial. Participants will follow time-restricted eating (14-hour fast, 10-hour eating window), and will be randomized to a diet low in energy density or the usual diet. Meals will be prepared in a metabolic kitchen and dispensed to participants. Dietitians will monitor dietary compliance. A blood sample will be drawn and body weight will be measured before starting the intervention and after completing it.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
40
Subjects will follow time-restricted eating of a low energy dense diet
Subjects will follow time-restricted eating of the usual diet
Pennington Biomedical Research Center
Baton Rouge, Louisiana, United States
Brain Insulin Resistance
Phosphorylation of serine 312 on insulin receptor substrate 1 in plasma neural-derived exosomes
Time frame: 8 weeks
Ketones
Ketones
Time frame: 8 weeks
Body weight
Body weight
Time frame: 8 weeks
Peripheral insulin resistance
Homeostasis model assessment of insulin resistance (HOMA-IR)
Time frame: 8 weeks
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