The Munich Cardiovascular Adaptation in Young Athletes Plus Study

Technical University of Munich250 enrolled

Overview

The aim of the 3-year longitudinal study is to investigate the cardiovascular system's response to training loads in young athletes. For the first time, these parameters will be examined alongside biochemical and metabolic laboratory measures, as well as body composition. The study focuses on the impact of training frequency and intensity, as well as performance, on cardiovascular structure and function. The following research questions are being investigated: What structural and functional cardiovascular changes can be observed in young athletes compared to the norm? What is the relationship between cardiac and vascular parameters depending on the athletic load (training frequency and intensity) as well as athletic performance? Do cardiac/vascular parameters change over the course of the study, and what role do athletic load (training frequency and intensity) as well as athletic performance play? What laboratory chemical changes can be observed in young athletes depending on the athletic load (training frequency and intensity) as well as athletic performance? What connections exist between laboratory chemical parameters and cardiac and vascular parameters in young athletes? Is there a correlation between structural and functional cardiovascular changes and body composition as well as eating behavior?

Study Type

OBSERVATIONAL

Enrollment

250

Conditions

Exercise

Eligibility

Sex: ALLMin age: 7 YearsMax age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Participants aged ≥7 and \<18 years, presenting for sports medical examination and meeting the criteria mentioned for a period of 3 years * Athletes participating in competitions, engaging in regular training in a primary sport, being members of a club or association, and training ≥3 hours per week * The last intensive training must have occurred 12 hours ago to ensure sufficient recovery * No acute infection, confirmed by a medical examination on the day of testing * No orthopedic injury, confirmed by a medical examination on the day of testing * No chronic disease, confirmed by a medical examination on the day of testing * Clearance for cardiopulmonary stress testing after a medical examination on the day of testing * Annual participation (1 time per year) in the sports medical examination for 3 years * Maintaining regular training, training duration ≥3 hours per week, and participation in competitions Exclusion Criteria: * Presence of an acute infection, acute orthopedic injury, or chronic disease * Missing consent from the participant and/or legal guardian

Locations (1)

Sportmedizinische Ambulanz für Kinder und Jugendliche

München, Bavaria, Germany

RECRUITING

Outcomes

Primary Outcomes

Vascular stiffness

Vascular stiffness of the A. carotis communis, sonographic assessment, result in (%) strain

Time frame: Once every year over 3 years

Peripheral and central blood pressure

Assessment via blood pressure cuff, result in (mmHg) Pulse Wave Velocity

Time frame: Once every year over 3 years

Left Ventricular internal end diastolic diameter (LVIDd)

Echocardiographic assessment, result in (mm)

Time frame: Once every year over 3 years

Left ventricular posterior wall end diastole (LVPWd)

Echocardiographic assessment, result in (mm)

Time frame: Once every year over 3 years

Interventricular septum thickness (IVSd)

Echocardiographic assessment, result in (mm)

Time frame: Once every year over 3 years

Left ventricular mass (LVM)

Echocardiographic assessment, result in (g)

Time frame: Once every year over 3 years

Relative wall thickness (RWT)

Echocardiographic assessment, result in (mm)

Time frame: Once every year over 3 years

Ejection fraction (EF)

Echocardiographic assessment, result in (%)

Time frame: Once every year over 3 years

Fractional shortening (FS)

Echocardiographic assessment, result in (%)

Time frame: Once every year over 3 years

Left ventricular diastolic function (E', E/E', A', E'/A', E-Wave, A-Wave, E/A)

Echocardiographic assessment, result in (cm/s)

Time frame: Once every year over 3 years

Left ventricular systolic function (S', S)

Echocardiographic assessment, result in (cm/s)

Time frame: Once every year over 3 years

Left Atrial Diameter and Right Atrial Diameter and Diameter/Body Surface Area

Echocardiographic assessment, result in (cm)

Time frame: Once every year over 3 years

Left Atrial and Right Atrial Volume/Body Surface Area

Echocardiographic assessment, result in (ml/m²)

Time frame: Once every year over 3 years

Left atrial peak longitudinal strain (L-PALS)

Echocardiographic assessment, result in (%)

Time frame: Once every year over 3 years

Left atrial peak contraction strain (L-PACS)

Echocardiographic assessment, result in (%)

Time frame: Once every year over 3 years

Left atrial total strain

Echocardiographic assessment, result in (%)

Time frame: Once every year over 3 years

Right atrial peak longitudinal strain (R-PALS)

Echocardiographic assessment, result in (%)

Time frame: Once every year over 3 years

Right atrial peak contraction strain (R-PACS)

Echocardiographic assessment, result in (%)

Time frame: Once every year over 3 years

Global longitudinal strain (GLS)

Echocardiographic assessment, result in (%)

Time frame: Once every year over 3 years

Intima-Media-Thickness (IMT)

Intima-Media-Thickness (IMT) of the A. carotis communis, sonographic assessment, result in (mm)

Time frame: Once every year over 3 years

Peripheral and central pulse pressure

Assessment via blood pressure cuff, result in (mmHg)

Time frame: Once every year over 3 years

Pulse Wave Velocity

Assessment via blood pressure cuff, result in (ms)

Time frame: Once every year over 3 years

Secondary Outcomes

Physical Fitness

Spiroergometric measure of VO2max

Time frame: Once every year over 3 years

Nutritional Status

Assessment of dietary habits and nutritional status via the validated Healthy Eating Index (HEI).Originally developed in the USA, it was adapted to the German recommendations on food consumption.Higher scores are associated with higher compliance with the official diet recommendations.

Time frame: Once every year over 3 years

Training Frequency

Assessment of training frequency via the MoMo activity questionnaire, result in (minutes/week)

Time frame: Once every year over 3 years

Medical history

Current illnesses/injuries,Vaccination status, Allergies, Medication, Dietary supplements, Alcohol- and nicotine consumption, Drug use, Energy Drinks, Dietary Habits, Menarche and menstrual cycle in girls Family history of cardiovascular diseases, Unclear deaths, Sudden cardiac death, Marfan syndrome Training history, Symptoms during exercise such as shortness of breath, dizziness/syncope, palpitations or chest pain

Time frame: Once every year over 3 years

Height

Measured via Stadiometer, result in (cm)

Time frame: Once every year over 3 years

Weight

Measured on scale, result in (kg)

Time frame: Once every year over 3 years

Body-Mass-Index

Calculated from Heigt and Weight, result in (kg/m²)

Time frame: Once every year over 3 years

Bodyfat percentage

Measured via bioelectric impedance scale, result in (%)

Central Contacts

Tobias Engl, Dipl. Sportwiss. Univ.

CONTACT

+49 89 289 24598 tobias.engl@tum.de

Jonas Haferanke, M.Sc.

CONTACT

+49 89 289 24579 jonas.haferanke@tum.de

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.

Time frame: Once every year over 3 years

Fat mass

Measured via bioelectric impedance scale, result in (kg)

Time frame: Once every year over 3 years

Fat-free mass

Measured via bioelectric impedance scale, result in (kg)

Time frame: Once every year over 3 years

Muscle mass

Measured via bioelectric impedance scale, result in (kg)

Time frame: Once every year over 3 years

Water content

Measured via bioelectric impedance scale, result in (L)

Time frame: Once every year over 3 years

Waist circumference

Measured via measuring tape, result in (cm)

Time frame: Once every year over 3 years

Hip circumference

Measured via measuring tape, result in (cm)

Time frame: Once every year over 3 years

Sitting height (cm)

Measured via Stadiometer, result in (cm)

Time frame: Once every year over 3 years

Erythrocytes

Venous blood sampling and laboratory analysis, result in (/pL),

Time frame: Once every year over 3 years

GOT (AST)

Venous blood sampling and laboratory analysis, result in (U/L)

Time frame: Once every year over 3 years

GPT (ALT)

Venous blood sampling and laboratory analysis, result in (U/L)

Time frame: Once every year over 3 years

GGT

Venous blood sampling and laboratory analysis, result in (U/L)

Time frame: Once every year over 3 years

Cholesterol

Venous blood sampling and laboratory analysis, result in (mg/dL)

Time frame: Once every year over 3 years

HDL-Cholesterol

Venous blood sampling and laboratory analysis, result in (mg/dL)

Time frame: Once every year over 3 years

Non-HDL (calc.)

Venous blood sampling and laboratory analysis, result in (mg/dL)

Time frame: Once every year over 3 years

LDL-Cholesterol

Venous blood sampling and laboratory analysis, result in (mg/dL)

Time frame: Once every year over 3 years

Creatinine

Venous blood sampling and laboratory analysis, result in (mg/dL)

Time frame: Once every year over 3 years

Uric acid

Venous blood sampling and laboratory analysis, result in (mg/dL)

Time frame: Once every year over 3 years

hsCRP

Venous blood sampling and laboratory analysis, result in (mg/dL)

Time frame: Once every year over 3 years

fT3

Venous blood sampling and laboratory analysis, result in (pg/mL)

Time frame: Once every year over 3 years

Glutathion peroxidase

Venous blood sampling and laboratory analysis, result in (U/L)

Time frame: Once every year over 3 years

Superoxide dismutase

Venous blood sampling and laboratory analysis, result in (U/mL)

Time frame: Once every year over 3 years

Endothelin-1

Venous blood sampling, blood plasma preparation and laboratory analysis, result in (pg/mL)

Time frame: Once every year over 3 years

Nitric Oxide

Venous blood sampling, blood plasma preparation and laboratory analysis, result in (μmol/L)

Time frame: Once every year over 3 years

Ferritin

Venous blood sampling, blood plasma preparation and laboratory analysis, result in (ng/mL)

Time frame: Once every year over 3 years

Leptin

Venous blood sampling, blood plasma preparation and laboratory analysis, result in (ng/mL)

Time frame: Once every year over 3 years

Training intensity

Assessment of training intensity via the MoMo activity questionnaire, result in (metabolic equivalent task-minutes/week)

Time frame: Once every year over 3 years

Hemoglobin

Venous blood sampling and laboratory analysis, result in (g/dL)

Time frame: Once every year over 3 years

HBE/MCH

Venous blood sampling and laboratory analysis, result in (pg)

Time frame: Once every year over 3 years

MCV

Venous blood sampling and laboratory analysis, result in (fL)

Time frame: Once every year over 3 years

Hematocrit

Venous blood sampling and laboratory analysis, result in (%)

Time frame: Once every year over 3 years

MCHC

Venous blood sampling and laboratory analysis, result in (g/dL)

Time frame: Once every year over 3 years

RDW (Ery)

Venous blood sampling and laboratory analysis, result in (%)

Time frame: Once every year over 3 years

Thrombocytes

Venous blood sampling and laboratory analysis, result in (Tsnd/µL)

Time frame: Once every year over 3 years

Leukocytes

Venous blood sampling and laboratory analysis, result in (/nL)

Time frame: Once every year over 3 years

Heart Rate

Assessment via blood pressure cuff, result in (bpm)

Time frame: Once every year over 3 years