Distinguishing Alcohol Intoxication, Cannabis Intoxication and Co-intoxication Using Electroencephalography (EEG)

Colorado State University99 enrolled

Overview

This is a randomized, parallel-group study designed to explore the differences between cannabis intoxication, alcohol intoxication and co-intoxication involving both alcohol and cannabis, utilizing electroencephalography (EEG) as well as more traditional intoxication measures such as breath alcohol concentration and balance metrics. If eligible for the study, participants will be randomized to complete one study session in our mobile laboratory, during which they will use either alcohol, cannabis (which will be self-administered, ad libitum) or both alcohol and cannabis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Cannabis Use Alcohol Use, Unspecified

Interventions

Eligibility

Sex: ALLMin age: 21 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 21-50 years old * Heavy drinkers (consuming more than 4 drinks/day or more than 14 drinks/week for men, or more than 3 drinks/day or more than 7 drinks/week for women) * Regular users of legal-market flower cannabis (at least 2x/week in past 3 months) * report simultaneously using alcohol and legal-market flower cannabis at least once per month in the past 3 months * English speakers. Exclusion Criteria: * Daily tobacco users * Diagnosed with or seeking treatment for alcohol use disorder (AUD) or other substance use disorder (SUD) * Females cannot be pregnant, breastfeeding or trying to become pregnant * Meet criteria for psychotic, bipolar or major depressive disorder with suicidal ideation, or history of these disorders, 5) Current use of psychotropic (except anti-depressants) * Report illicit drug use in past 60-days or fail drug screen on the day of the study appointment * Major medical condition contraindicating alcohol and/or cannabis consumption.

Outcomes

Primary Outcomes

Electroencephalography (EEG) Objective Cognitive Function Measures--Amplitude (microvolts)

The EEG amplitude (measured in microvolts) will be obtained while participants perform the speeded visual flanker task

Time frame: Immediately pre-substance use, 1-hour post-use, 2-hours post-use, 4-hours post-use

Electroencephalography (EEG) Objective Cognitive Function Measures--Latency (milliseconds)

The EEG latency (measured in milliseconds) will be obtained while participants perform the speeded visual flanker task

Time frame: Immediately pre-substance use, 1-hour post-use, 2-hours post-use, 4-hours post-use

Standing postural stability

An iPod Touch will be attached to each participant's hip with a simple elastic/Velcro strap. An app on the device will record fine grained movements while they try to stand as still as possible for 30-60 seconds under four conditions that vary in terms of demand on the proprioceptive system (eyes open, eyes closed), and on a stable vs. soft (foam) surface.

Time frame: Immediately pre-substance use, 1-hour post-use, 2-hours post-use, 4-hours post-use

Distinguishing Alcohol Intoxication, Cannabis Intoxication and Co-intoxication Using Electroencephalography (EEG)

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Central Contacts