the effects of high-intensity interval training on myocardial function will be studied in a group of patients under medical treatment for the components of metabolic syndrome.
Objective: To analyze the effects of high-intensity interval training (HIIT) on myocardial function of metabolic syndrome patients. Methods and design. Randomized clinical trial with a control group. Project was developed in association with the regional general hospital. Pre and post-intervention evaluation after 16 weeks of training for the HIIT group. Subjects: Recruited using adverts published on public medical center boards. Up to 30 subjects per group (HIIT and CONTROL) will be recruited (at least 20% women) Measurements. Echocardiography: Global longitudinal strain (GLS), Mitral filling parameters, myocardial dimensions, and myocardial wall thickness. Cardiorespiratory fitness: Maximal oxygen consumption, Maximal power output, Maximal oxygen pulse. Clinical: Metabolic syndrome components and derived variables (e.g., triglycerides/high-density lipoprotein ratio) Body composition by anthropometric measurements and dual-energy X-ray absorptiometry.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
80
supervised exercise conducted on stationary bikes after individualized intensity prescription.
University of Castilla-La Mancha
Toledo, Castille-La Mancha, Spain
Changes in global longitudinal strain
response to myocardial strain after intervention. Assessed by echocardiography, measured as a percentage
Time frame: up to 16 weeks
changes in cardiorespiratory fitness
changes in maximal oxygen consumption measured in litres/min, all assessed by a cardiopulmonary exercise test in cycle-ergometer with breath by breath gas analysis.
Time frame: up to 16 weeks
changes in metabolic syndrome z-score
Adimensional variable used to assess in a unified score, the changes in the components of metabolic syndrome. The z-score is based on the cut-off points ot the components(fasting serum concentrations of glucose, triglycerides, and high density lipoprotein, all measured in mg/DL), waist circumference measured in cm, systolic and diastolic blood pressure measured in mm Hg), and the variance of each variable among participants assessed by the standard deviation.
Time frame: up to 16 weeks
changes in visceral fat
changes in visceral fat after intervention, assessed by dual-energy x-ray absortiometry. Measured in kg.
Time frame: up to 16 weeks
changes in left ventricle passive filling (E wave)
changes in early diastolic mitral inflow velocity (E wave), assessed by echocardiography. Measured in m/seg.
Time frame: up to 16 weeks
changes in early diastolic mitral annulus velocity (e' wave)
changes in early diastolic mitral annulus velocity (e' wave), assessed by echocardiography. Measured in m/seg.
Time frame: up to 16 weeks
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changes in estimated left ventricle filling pressures (E/e')
changes in estimated left ventricle filling pressures by E/e' ratio (Peak E-wave velocity divided by the peak e' velocity) obtained by echocardiography, being E and e' measured in m/seg.
Time frame: up to 16 weeks