Effectiveness of Repeated Amiodarone Dosing Regimen Versus Standard Dosing Regimen in Atrial Fibrillation Patient With Rapid Ventricular Response

Police General Hospital, Thailand24 enrolled

Overview

The goal of this clinical trial is to compare in atrial fibrillation patient with rapid ventricular response. The main question it aims to answer are Effectiveness of Repeated Amiodarone dosing regimen versus standard dosing regimen in Atrial fibrillation patient with rapid ventricular response Participants will receive Amiodarone iv treatment with different regimen * Repeated dosing regimen * Standard dosing regimen

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Atrial Fibrillation

Interventions

AmiodaroneDRUG

Assess the effectiveness of repeated bolus dosing strategies of amiodarone.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age above 18 years old * Atrial fibrillation with rapid ventricular response patient (ventricular rate \> 110) Exclusion Criteria: * Baseline EKG Corrected QT interval (QTc) \< 500 msec * History of pulmonary fibrosis * History of Cirrhosis * Cardiac Index \<2.2 L/min/m2 or Cardiogenic shock * Unstable arrhythmia * Receive amiodarone within 3 months prior to present illness * Pregnancy * Amiodarone or Iodine allergy

Locations (1)

Police general hospital

Bangkok, Thailand

Outcomes

Primary Outcomes

Heart rate

Percentage of patients who have Atrial fibrillation with rapid ventricular response, the percentage of patients who have heart rate below 110 bpms at 6 hours after receiving a repeated amiodarone bolus and loading dose regimen to the percentage of patients who have heart rate below 110 bpms at 6 hour after a conventional amiodarone IV loading dose regimen

Time frame: 6-hours after receiving amiodarone bolus

Secondary Outcomes

Normal sinus rhythm at 24 hours

Percentage of patients who develop Atrial fibrillation with rapid ventricular response, the percentage of patients who have converted to sinus rhythm at 24-hours after receiving a repeated amiodarone bolus and loading dose regimen to the percentage of patients who have converted to sinus rhythm after a conventional amiodarone IV loading dose regimen

Time frame: 24-hours after receiving amiodarone bolus

Heart rate

Percentage of patients who have Atrial fibrillation with rapid ventricular response, the percentage of patients who have heart rate below 110 bpms at 24 hours after receiving a repeated amiodarone bolus and loading dose regimen to the percentage of patients who have heart rate below 110 bpms at 6 hour after a conventional amiodarone IV loading dose regimen

Time frame: 24-hours after receiving amiodarone bolus

Major adverse cardiovascular events

Number of MACE \[MACE defined as acute myocardial infarction (AMI), stroke, or cardiovascular death\]

Time frame: 30 days after receiving amiodarone bolus

Phlebitis

Rate of phlebitis complication during amiodarone infusion

Time frame: 24-hours after receiving amiodarone bolus

Changed in heart rate

Data from ClinicalTrials.gov

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