In our study, there are 33 healthy children with normal weight (control group) and 52 obese children who will be treated with metformin. To observe the efficacy of the 3-month treatment before and after metformin treatment, Zn, Zinc α-2 Glycoprotein (ZAG), Peroxisome proliferation activating receptor γ (PPARγ), Leptin (LEP) and Adiponectin (ADIPO) levels were compared, as well as anthropometric measurements and routine biochemistry tests.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
52
Only obese children with insulin resistance were treated with metformin.
Erciyes University
Kayseri, Melikgazi, Turkey (Türkiye)
Insulin resistance (HOMA-IR) level
HOMA-IR is a condition in which the body's cells become less responsive to the effects of insulin. This means that the body needs more insulin to achieve the same effects, such as regulating blood sugar levels
Time frame: three months
Weight loss rate
Weight loss rate is typically defined as the amount of weight lost over a specific period of time.
Time frame: three months
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