Improvement of Depression With Use of ATP

Diffusion Tensor Imaging

Diffusion Tensor Imaging(DTI) is used to detect changes in fractional anisotropy (FA) maps of brain white matter fiber in major depressive patients.

Time frame: Baseline, two weeks, and four weeks

Diffusion Spectral Imaging

Diffusion Spectral Imaging(DSI) is a newly proposed modification of DTI that allows potentially improved visualization of the complex white matter architecture.

Time frame: Baseline, two weeks, and four weeks

Quantitative susceptibility mapping

Quantitative susceptibility mapping(QSM) is widely used by the imaging research community in applications to detect iron. Tissue can become magnetized in response to a magnetic field, and the extent of magnetization is known as susceptibility, which arises from unpaired electrons in iron or external sources such as contrast agents. QSM permits visualization of the sizes and shapes of iron sources, delivers precise estimates of iron concentrations (units: parts per billion \[ppb\] or parts per million \[ppm\]).

Time frame: Baseline, two weeks, and four weeks

Monetary Incentive Delay Task

Participants see cues that they may win or lose money, then wait for a variable anticipatory delay period, and respond to a rapidly presented target with a single button press to try to either win or avoid losing money. Task-based functional magnetic resonance imaging (fMRI) will be used to assess neural activity during the Monetary Incentive Delay Task.

Time frame: Baseline, two weeks, and four weeks

Emotional faces processing task

Volunteers responded with a button press to each face with different emotions, indicating whether it was male or female. Task-based functional magnetic resonance imaging (fMRI) will be used to assess neural activity during the emotional faces processing task.

Time frame: Baseline, two weeks, and four weeks

Resting state functional connectivity

Resting-state functional connectivity will be assessed over a 10-minute period, focusing on functional connectivity between the medial prefrontal cortex and Lhb.

Time frame: Baseline, two weeks, and four weeks

Hamilton Anxiety Scale

Changes in Hamilton Anxiety Scale(HAMA-14). Score range from 0-56, higher scores mean a worse outcome.

Time frame: Baseline, one week, two weeks, four weeks, twelve weeks, twenty-four weeks

Clinical Global Impression

Changes in Clinical Global Impression(CGI)

Time frame: Baseline, one week, two weeks, four weeks, twelve weeks, twenty-four weeks

Snaith-Hamilton Pleasure Scale

Changes in Snaith-Hamilton Pleasure Scale(SHAPS). Score range from 14-56, higher scores mean a worse outcome.

Time frame: Baseline, one week, two weeks, four weeks, twelve weeks, twenty-four weeks

Insomnia Severity Index

Changes in Insomnia Severity Index(ISI). Score range from 0-28, higher scores mean a worse outcome.

Time frame: Baseline, one week, two weeks, four weeks, twelve weeks, twenty-four weeks

Columbia-Suicide Severity Rating Scale

Changes in Columbia-Suicide Severity Rating Scale(C-SSRS)

Time frame: Baseline, one week, two weeks, four weeks, twelve weeks, twenty-four weeks

Antidepressants Side Effects

Number of Participants with antidepressants side effects(SERS)

Time frame: One week, two weeks, four weeks, twelve weeks, twenty-four weeks

C-reactive protein

Changes in C-reactive protein(CRP)

Time frame: Baseline, two weeks, four weeks, twelve weeks, twenty-four weeks

Tumor Necrosis Factor α

Changes in Tumor Necrosis Factor α(TNF-α)

Time frame: Baseline, two weeks, four weeks, twelve weeks, twenty-four weeks

Interleukin- 6

Changes in interleukin- 6(IL-6)

Time frame: Baseline, two weeks, four weeks, twelve weeks, twenty-four weeks

N-back task

Changes in reaction time and accuracy

Time frame: Baseline, two weeks, four weeks, twelve weeks, twenty-four weeks

Attention network test

Changes in reaction time and accuracy

Time frame: Baseline, two weeks, four weeks, twelve weeks, twenty-four weeks

Psychomotor vigilance task

Changes in reaction time and accuracy

Time frame: Baseline, two weeks, four weeks, twelve weeks, twenty-four weeks

Hamilton Depression Scale

Changes in HAMD-24. Score range from 0-76, higher scores mean a worse outcome.

Time frame: Baseline, one week, twelve weeks, twenty-four weeks

Montgomery and asberg Depression Rating Scale

Changes in Montgomery and asberg (MADRS) Depression Rating Scale. Score range from 0-60, higher scores mean a worse outcome.

Time frame: Baseline, one week, two weeks, four weeks, twelve weeks, twenty-four weeks

Beck Depression Inventory

Changes in Beck Depression Inventory(BDI). Score range from 0-63, higher scores mean a worse outcome.

Time frame: Baseline, one week, two weeks, four weeks, twelve weeks, twenty-four weeks