The goal of this clinical trial is to compare hemodynamic response (MAP, SBP, DBP and HR) between scalp block and intravenous esmolol while skull pins application in patients undergoing elective supratentorial craniotomy under general anesthesia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
90
Receive 30 ml of 0.25% bupivacaine with 1% lidocaine (1:1) with adrenaline 1:200,000 infiltration for 10 minutes before skull pins application.
Receive Intravenous esmolol 1 mg/kg bolus over 1 minute before skull pins application
Khon Kaen University
Khon Kaen, Naimuang, Muang, Thailand
MAP
Mean arterial pressure
Time frame: Baseline, 1 minute before skull pins, then 30 sec, 60 sec, 90 sec, 120 sec, 180 sec and 300 sec after skull pins
SBP
Systolic blood pressure
Time frame: Baseline, 1 minute before skull pins, then 30 sec, 60 sec, 90 sec, 120 sec, 180 sec and 300 sec after skull pins
DBP
Diastolic blood pressure
Time frame: Baseline, 1 minute before skull pins, then 30 sec, 60 sec, 90 sec, 120 sec, 180 sec and 300 sec after skull pins
HR
Heart rate
Time frame: Baseline, 1 minute before skull pins, then 30 sec, 60 sec, 90 sec, 120 sec, 180 sec and 300 sec after skull pins
BIS
Bispectral index
Time frame: Baseline, 1 minute before skull pins, then 30 sec, 60 sec, 90 sec, 120 sec, 180 sec and 300 sec after skull pins
Cumulative postoperative opioids consumption
Opioids consumption
Time frame: 6 hours and 24 hours postoperatively
Postoperative adverse events
Incidence (%)
Time frame: Within first 24 hours postoperatively
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