Interventional Trial to determine the Effect of different PEEP levels on Cardiac output and right-ventricular function in mechanically ventilated children \< 5 years of age with congenital heart disease.
Different PEEP-levels will be applied during invasive mechanical ventilation to describe Cardio-pulmonary interactions in children with congenital heart disease (CHD). An additional trial with the same study protocol is planned in a cohort of children with primarily pulmonary disease without CHD after completion of this trial. Esophageal pressure-monitoring, Ultrasound, respiratory mechanics and electrical impedance tomography will be used
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
58
Application of different PEEP-Levels during invasive mechanical ventilation
Deutsches Herzzentrum der Charité
Berlin, State of Berlin, Germany
UMCG
Groningen, Netherlands
Cardiac Output
change in CO during intervention
Time frame: 1 year
TAPSE (cm)
Excursion of the TV annulus
Time frame: 1 year
respiratory mechanics
Tidal Volume (ml/kg)
Time frame: 1 year
TAPSV (cm/s)
systolic excursion of the TV annulus with tissue doppler
Time frame: 1year
Global Strain RV (%/sec)
shortening of the RV myocardium during systole
Time frame: 1year
Lung Compliance (ml/Min/kg)
compliance of lung tissue
Time frame: 1year
Esophageal Pressure (mbar)
monitoring with balloon
Time frame: 1year
EIT
Tidal Volume distribution
Time frame: 1year
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