Real-World HRU and Costs in DLBCL Pts With Tisa-cel and Axi-cel, a Medicare Study.

Novartis Pharmaceuticals613 enrolled

Overview

This was a retrospective non-interventional cohort study design using the Centers for Medicare and Medicaid Services (CMS) 100% Medicare data (2015Q1-2020Q4). Eligible adult patients with r/r DLBCL who were treated with CAR-T therapy were identified from the CMS 100% Medicare data. Patients who received chimeric antigen receptor modified T cell (CAR-T) therapy were further classified into tisa-cel and axi-cel cohorts based on the type of CAR-T treatment received. The index date was defined as the date of tisa-cel or axi-cel therapy administration. Baseline period was defined as three months prior to the index date. Study period was defined from the index date to the end of health plan coverage based on insurance enrollment file or death, whichever occurred earlier.

Study Type

OBSERVATIONAL

Enrollment

613

Conditions

Diffuse Large B-cell Lymphoma

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients had at least one International Classification of Diseases, 10th Revision (ICD-10) diagnosis code for DLBCL. * Patients received CAR-T therapy, including both tisa-cel and axi-cel, following DLBCL diagnosis. The administration date of CAR-T therapy was defined as the index date. * Patients were at least 18 years of age as of the index date. * Patients had at least three months of continuous health plan enrollment before the index date. Exclusion Criteria: * Patients who had a medical claim associated with a clinical trial within one month before and after the index date. * Patients who had zero cost on index date for CAR-T infusion.