SPT for Sensitization of Collagen Dressing

Inclusion Criteria: * Age: 18-70 * Sex: Male \& Female * Fitzpatrick: I-V, minimum 10% of panel Fitzpatrick V. * Individuals who will be able to read, understand and give an informed consent relating to the study they are participating in. * Individuals who will be free of any dermatological or systemic disorder, which in the Investigator's opinion, could interfere with the study results. * Individuals who will be in general good health and who will complete a preliminary medical history form mandated by the testing facility. * Individuals who will be able to and agree to cooperate with the Investigator and clinical staff. * Individuals who will agree to have test products applied in accordance with the protocol and are able to complete the full course of the study. * Individuals who have not participated in a similar study in the past 30 days. * Individuals who agree to refrain from sun tanning/bathing and prolonged exposure to sunlight (outdoors). * Individuals who are willing to refrain from wetting, wiping, cleanse, and covering the test sites (volar surface of the forearms) between the baseline and up to 48-hour time points. * Female volunteers who are willing to undergo a urine pregnancy test. * Individuals willing to refrain from vitamin C (Emergen-C), orange juice and vitamin water for the study duration and two days prior to the SPT test. Exclusion Criteria: * Individuals who are currently taking any medications (topical or systemic) that may mask or interfere with the test results (specifically, corticosteroids, topical and/or systemic \[except nasal steroids\], non steroidal anti-inflammatory drugs \[e.g. ibuprofen, Advil, Motrin, aspirin \> 325mg/day\], antihistamines, and topical/oral immunosuppressive medications). * Individuals who have a history of any acute or chronic disease that might interfere with or increase the risk on study participation. (e.g., systemic lupus erythematosus, rheumatoid arthritis, HIV positive). * Individuals who are diagnosed with chronic skin allergies (atopic dermatitis/eczema) or recently treated skin cancer within the last 12 months. * Individuals who have damaged skin in close proximity to test sites (e.g., sunburn, uneven skin pigmentation, tattoos, scars, excessive hair, active acne papules or other disfigurations). * Individuals who control their diabetes using insulin. * Individuals with any history, which in the Investigator's opinion, indicates the potential for harm to the subject or places the validity of the study in jeopardy. * Female volunteers who indicate that they are pregnant or are planning to become pregnant or nursing. * Individuals with a known history of hypersensitivity to any cosmetics, personal care products, fragrances, and/or adhesives. * Individuals that have a history of dermatographism. * Individuals have a history of frequent skin irritation. * Employees of ALS. * Individuals with a known fish allergy.