Endotypic Stability in CRS

Thomas Jefferson University200 enrolled

Overview

A Case control study with 150 cases and 50 controls will be conducted. Immunologic (cytokines measurements in nasal secretions and sinonasal tissues), histopathologic (tissue eosinophilia) and clinical parameters (Lund-Mackay and Lund-Kennedy score, lung function tests), surveys (SNOT- 22, SF-36 quality of life survey) will be compared between different groups of patients

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Chronic Sinusitis

Interventions

no interventionOTHER

no intervention

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with Chronic sinusitis (with or without polyps) * Undergoing endoscopic sinus surgery during the study period * More than 18 years * No chronic illness/ malignancy

Locations (1)

Thomas Jefferson University Department of Otolaryngology

Philadelphia, Pennsylvania, United States

RECRUITING

Outcomes

Primary Outcomes

Endotypic markers

The primary outcome measure assessed through this study is the presence of endotypic markers including: IL-5, IFN-gamma, IL-17a, TNF-alpha, and IL-22 in tissue biopsy samples across multiple racial/ethnic groups.

Time frame: 1 year

Secondary Outcomes

SF-36

Differences in SF-36 scores between ethnic groups.

Time frame: 1 year

SNOT-22

Differences in SNOT-22 scores between ethnic groups.

Time frame: 1 year

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.