Exploring the Interaction Between Metabolic Disorders and NLPR3 Inflammasome Activation in DR Inflammatory Damage

Inclusion Criteria: 1. Patients \> 40 years old. 2. CON (non diabetes control group)：patients undergoing phacoemulsification surgery. 3. NDR (non diabetes retinopathy diabetes patients): patients with diabetes history and undergoing phacoemulsification surgery. 4. NPDR (non proliferative diabetes retinopathy): patients with history of diabetes, fundus microangiopathy shown by fundus fluorescein angiography, including microangioma, hard exudation, wadding exudation and other non proliferative diabetes retinopathy signs, and did not receive invasive ophthalmic treatment within 3 months. 5. PDR (proliferative diabetes retinopathy): patients with a history of diabetes, fundus neovascular lesions shown by fundus fluorescein angiography, and did not receive invasive ophthalmic treatment within 3 months. 6. Patients voluntarily signed informed consent. Exclusion Criteria: 1. CON (non diabetes control group)：patients with a history of other ophthalmic operations. 2. NDR (non diabetes retinopathy diabetes patients): patients with fundus changes of diabetes retinopathy or other ophthalmic surgery history. 3. NPDR (non proliferative diabetes retinopathy): patients with fundus neovascular lesions shown by fundus fluorescein angiography. 4. PDR (proliferative diabetes retinopathy):patients undergoing vitrectomy。 5. Patients with active ocular inflammation, high myopia, pregnancy.