GS-441524 for COVID-19 SAD, FE, and MAD Study in Healthy Subjects

Inclusion Criteria: * Must be able to verbalize understanding of the consent form, able to provide written informed consent, and verbalize willingness to complete study procedures, be able to comply with protocol requirements, rules and regulations of study site, and be likely to complete all the study interventions. * Must be considered a healthy male or healthy female of nonchildbearing potential. * Women of nonchildbearing potential are considered women who: 1. Do not have a uterus, or 2. Are surgically sterile (for example: has undergone complete hysterectomy, bilateral oophorectomy, or tubal ligation; should be verified by medical documentation), or 3. Have permanent cessation of ovarian function due to ovarian failure or surgical removal of the ovaries, or 4. Are postmenopausal as defined by 12 months or more of spontaneous amenorrhea as confirmed by a follicle-stimulating hormone (FSH) level \>30 mIU/mL. * Between 18 and 55 years of age, inclusive. * Body mass index (BMI) within 18.0 to 32.0 kg/m2, inclusive. * Minimum weight of at least 50.0 kg at screening. * Male subjects who are sexually active with female partners of childbearing potential must use, with their partner, a condom plus an approved method of effective contraception from the time of screening until 90 days after the last dose of investigational medicinal product (IMP). Additionally, male subjects must agree to not donate sperm during the study and for at least 90 days from the last dose of IMP. Effective methods of contraception are: 1. Combined (estrogen- and progestogen-containing) hormonal contraception associated with inhibition of ovulation (oral, intravaginal, or transdermal) 2. Progestogen-only hormonal contraception (oral, injectable/implantable, or intrauterine hormone-releasing system) 3. Implantable intrauterine device 4. Surgical sterilization (for example, vasectomy or bilateral tubal ligation; should be verified by medical documentation) 5. Male condom with spermicidal gel/foam or with female cap or diaphragm (double barrier) * Must have normal renal function (estimated glomerular filtration rate \[eGFR\] \>75 mL/min/1.73 m2, as calculated by the CKD-EPI 2021 creatinine formula). Exclusion Criteria: * Have a medical history of clinically significant neurological, cardiovascular, renal, hepatic, chronic respiratory or gastrointestinal disease, or psychiatric disorder as judged by an Investigator. * Have clinically significant abnormal biochemistry, hematology, or urinalysis results as judged by an Investigator. * Have disorders that may interfere with drug absorption, distribution, metabolism, and excretion processes. * Positive test results for human immunodeficiency virus (HIV)-1/HIV-2 antibodies, hepatitis B surface antigen (HBsAg), or hepatitis C virus (HCV) antibody. * Serious cardiac illness or other medical condition including, but not limited to: 1. Uncontrolled arrhythmias 2. History of congestive heart failure 3. Corrected QT value with Fridericia's formula (QTcF) \>450 msec for males and \>470 msec for females or history of prolonged QT syndrome 4. Have a blood pressure reading outside of the following range: systolic blood pressure \<86 mmHg or \>149 mmHg and diastolic blood pressure \<50 mmHg or \>94 mmHg * History of pancreatitis and history of hepatic or biliary disease, including those with known history/diagnosis of Gilbert's syndrome. Subjects with gall bladder removal \<90 days prior to screening. * Regular alcohol consumption in males \>21 units per week and females \>14 units per week (1 unit=12 ounces of beer, 1.5 ounces of spirit, or 5 ounces of wine) within 12 months prior to screening. * Positive test result for alcohol and/or drugs of abuse at screening or prior to the first IMP administration. * Current smokers and those who have smoked within 90 days prior to the first IMP administration. Current users of e cigarettes and nicotine replacement products, and those who have used these products within 90 days prior to the first IMP administration. * Concurrent treatment or treatment with an investigational drug within 30 days prior to the first dose of IMP. * Blood donation of approximately 500 mL within 56 days or plasma donation within 7 days of screening. * Subjects who are taking, or have taken, any prescribed or over-the-counter drugs (other than a maximum of 2 g per day of acetaminophen, hormone replacement therapy, hormonal contraception) or herbal remedies in the 14 days before randomization. Exceptions may apply on a case-by-case basis if considered not to interfere with the objectives of the study, as agreed by the Investigator and Sponsor's Medical Monitor. * Known allergy or intolerance to remdesivir. * Any condition that, in the opinion of an Investigator, would interfere with evaluation or interpretation of subject safety or study results. * Affiliated with, or a family member of, site staff directly involved in the study, or anyone with a financial interest in the outcome of the study. * Subjects who are unable, in the opinion of an Investigator, to comply fully with the study requirements.