The incidence and prevalence of metabolic risk factors such as obesity, hypertension, diabetes, and dyslipidemia, as well as cardiovascular diseases (CVD), are continuously rising among the occupational population in China, primarily comprising the middle-aged and young adults. Unhealthy lifestyles and declining physical fitness are independent risk factors affecting cardiovascular health. Additionally, the level of physical fitness is influenced by postnatal lifestyles. Lifestyle factors related to cardiovascular health in the occupational population encompass various aspects, including smoking, physical activity, diet, sleep, psychological stress, etc. These factors may interact or have a synergistic effect, necessitating a comprehensive assessment. This project proposes a prospective cohort study design to establish a monitoring cohort for lifestyle and physical fitness among the occupational population. The study will track and follow individuals with or without any CVD metabolic risk factors, collecting information on general status, lifestyle, physical fitness, and health examination data. Exposure factors such as lifestyle and physical fitness will be measured annually, and the occurrence of CVD-related health outcomes will be observed. The aim is to develop a comprehensive evaluation index for cardiovascular health lifestyle, analyze the direct and indirect impacts of lifestyle and physical fitness on the occurrence and development of CVD, and explore potential mediating and moderating effects of physical fitness in the association between lifestyle and cardiovascular health.
Study Type
OBSERVATIONAL
Enrollment
18,512
Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College
Beijing, Beijing Municipality, China
RECRUITINGthe composite end point of new major adverse cardiovascular events
including cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization and unstable angina pectoris requiring hospitalization
Time frame: 10 years
new incidence of each major adverse cardiovascular events
new incidence of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization, unstable angina requiring hospitalization and other major adverse cardiovascular events
Time frame: 10 years
new incidence of cancer
new incidence of cancer and all-cause death
Time frame: 10 years
new incidence of all-cause death
new incidence of all-cause death
Time frame: 10 years
level of systolic pressure
The level of systolic pressure measured at each follow-up evaluation time point
Time frame: 10 years
level of diastolic pressure
The level of diastolic pressure measured at each follow-up evaluation time point
Time frame: 10 years
level of blood lipid
The level of blood lipid measured at each follow-up evaluation time point
Time frame: 10 years
level of BMI
The level of BMI (weight and height will be combined to report BMI in kg/m\^2) measured at each follow-up evaluation time point
Time frame: 10 years
level of maximal oxygen uptake (VO2max)
The level of VO2max which is obtained by submaximal exercise testing on cycle ergometer with two-stage workload to assess cardiorespiratory fitness measured at each follow-up evaluation time point
Time frame: 10 years
level of metabolic equivalents (METs)
The level of METs which is obtained by submaximal exercise testing on cycle ergometer with two-stage workload to assess cardiorespiratory fitness measured at each follow-up evaluation time point
Time frame: 10 years
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