The Influences of Single Chamber vs. Multi-chamber Blood Flow Restriction Cuffs

N/AActive Not RecruitingNCT06276673

Salisbury University35 enrolled

Overview

The purpose of this study is to investigate the use of single (SC) and multi-chamber (MC) blood flow restriction (BFR) cuff exercise on indices of arterial stiffness, muscle morphology, and participant perception.

Thirty adults aged 18-40 years old will undergo three treatment sessions (control (no BFR), SC BFR, and MC BFR) in a randomized order separated by one week. A familiarization session will also occur one week before starting the treatment period. Each subject will undergo a series of tests including anthropometry, ultrasonography of the carotid artery, applanation tonometry, ultrasonography of the vastus lateralis, blood pressure acquisition, body composition, and maximal strength assessments (1RM). The exercise trial will consist of sets of dumbbell wall squats performed to failure with a 2-seconds concentric and 2-seconds eccentric cadence, at 20% of their 1RM using 60% of the supine limb occlusion pressure (LOP) with 1-minute rest intervals. Assessments will be performed immediately before and after the exercise bout during each treatment session. Two-way ANOVAs will be used to examine the main effects of treatment and treatment-order interaction on pulse wave velocity, muscle cross-sectional area, and perceptual response.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Blood Vessel Disease Muscle Edema

Interventions

DelfiDEVICE

Cuffs will be worn throughout the entire training session. Training session consist of lower intensity wall squats. Four sets of wall squats will be performed to failure. Arterial stiffness and muscle morphological assessments will be conducted before and after the exercise.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Physically active (\> 1,000 MET/min/wk) for at least six months. 2. Weight stable for previous 6 months (+/-2.5 kg) 3. Female subjects only- reported regular menstrual cycles for the last 2 years Exclusion Criteria: 1. BP\>140/90 mmHg 2. BMI\>40 kg/m2 3. Diabetes 4. Familial hypercholesterolemia 5. Past or current history of CHD, stroke or major CVD events. Respiratory diseases (not including asthma), endocrine or metabolic, neurological, or hematological disorders that would compromise the study or the health of the subject. 6. Women must not be pregnant, plan to become pregnant during the study, or be nursing 7. Active renal or liver disease 8. All medications and supplements that influence dependent variables\* 9. Recent surgery \< 2 months 10. Alcohol abuse 11. Sleep apnea 12. Claustrophobia

Locations (1)

Salisbury University

Salisbury, Maryland, United States

Outcomes

Primary Outcomes

Arterial Stiffness

A measurement of vascular health.

Time frame: Prior to and 10-minutes after the exercise intervention

Muscle Morphology

A measurement of vastus lateralis cross sectional area

Time frame: Prior to and immediately after the exercise intervention

Data from ClinicalTrials.gov

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