A Study Using 18F-FAPI PET to Evaluate Treatment Response in Pancreatic Adenocarcinoma

N/ACompletedNCT06277206

Zhejiang University59 enrolled

Overview

To explore the potential utility of 18F-FAPI-04 PET/CT for pathologic response evaluation to systemic treatment in PDAC

Study Type

OBSERVATIONAL

Enrollment

Conditions

18F-FAPI Pancreas Adenocarcinoma Systemic Treatment Pathologic Response

Interventions

18F-FAPI PET/CTDIAGNOSTIC_TEST

Enrolled patients underwent 18F-FAPI PET/CT at diagnosis. And preoperative 18F-FAPI PET/CT was completed in the patients met the criteria for conversion surgery after systemic treatment. The correlation between changes of parameters before and after treatment and pathologic response was analyzed.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * suspected to have pancreatic cancer by radiological imaging * planned systemic treatment * possibility of conversion surgery * willingness to participate the study Exclusion Criteria: * without pathologically confirmed pancreatic cancer * poor performance status or organ functions that cannot meet the systemic treatment requirements * metastatic disease * pregnant patients

Locations (1)

First Affiliated Hospital, Medical College of Zhejiang University

Hangzhou, Zhejiang, China

Outcomes

Primary Outcomes

Change of Maximum standardized uptake value

Change of SUVmax before and after treatment

Time frame: Baseline and preoperation

Change of Mean standardized uptake value

Change of SUVmean before and after treatment

Time frame: Baseline and preoperation

Secondary Outcomes

Maximum standardized uptake value

Baseline SUVmax at diagnosis

Time frame: Baseline

Mean standardized uptake value

Baseline SUVmean at diagnosis

Time frame: Baseline

Metabolic Tumor Volume

Baseline MTV at diagnosis

Time frame: Baseline

Total Lesion FAP expression

Baseline TLF at diagnosis

Time frame: Baseline

Change of Metabolic Tumor Volume

Change of MTV before and after treatment

Time frame: Baseline and preoperation

Change of Total Lesion FAP expression

Change of TLF before and after treatment

Time frame: Baseline and preoperation

Data from ClinicalTrials.gov

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