Evaluation of Impedance Cardiography for Assessing Hemodynamic Shifts in Patients With LA-NSCLC During Treatment.

Inclusion Criteria: 1. had untreated histologically or cytologically confirmed NSCLC 2. be between the age of 18 and 75 3. had unresectable stage IIIA-IIIC disease, as defined by the AJCC 8th edition staging system 4. had an Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0\~1 5. had adequate bone marrow function (neutrophil count ≥1.5x109/L, hemoglobin concentration ≥90 g/L, platelet ≥100x109/L), kidney function (serum creatinine clearance ≥50 ml/min) and liver function (serum bilirubin ≤1.5 times upper limit of normal (ULN), aspartate transaminase (AST) and alanine transferase (ALT) ≤2.5 ULN) 6. had a forced expiratory volume in 1 second (FEV1) of ≥0.8L. Exclusion Criteria: 1. mixed small cell and NSCLC histology 2. life expectancy lower than 12 weeks 3. history of another primary malignancy 4. poorly controlled intercurrent illness 5. female in pregnancy or breast-feeding and any situation not suitable for this study judged by researchers 6. patients with contraindications to 6MWT, including unstable angina pectoris or myocardial infarction within the past month, systolic blood pressure (SBP) over 180mmHg, diastolic blood pressure (DBP) over 100mmHg, muscle strength below grade 3, and severe spasm.