Correlation Between Expression of Hormonal Receptors, Clinical Data, and Methylation Profile in Meningiomas (MethylRH-M)

Central Hospital, Nancy, France180 enrolled

Overview

This research aims to explore the relationship between hormonal receptor expression and the clinical and histopathological characteristics of meningiomas. The underlying hypothesis is that hormonal receptor expression, as well as the methylation profile of their gene promoters, are associated with specific aspects of meningiomas and patients' clinical outcomes. The main objective is to study the correlation between the immunohistochemical expression of hormonal receptors and clinicopathological data. The secondary objectif is to study the correlation between the methylation profile of hormonal receptor gene promoters and their immunohistochemical expression.

Study Type

OBSERVATIONAL

Enrollment

180

Conditions

Meningioma

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who underwent surgery for a meningioma at the University Hospital of Nancy between 2000 and 2022. Exclusion Criteria: * Patients who did not express their consent to participate in the study. * Patients with grade 2 or 3 meningiomas whose samples are no longer available or in insufficient quantity to perform an immunohistochemical study. * Patients with grade 1 meningiomas not selected by randomization. * Patients withdrawing their consent.

Outcomes

Primary Outcomes

immunohistochemical expression of different hormonal receptors

Evaluated on FFPE sections