In order to clarify the clinical efficacy of electroacupuncture on inhibiting systemic inflammatory response, improving respiratory mechanics parameters and prognosis in patients with sepsis-related ARDS.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
264
1. Experimental group: Sterile stainless steel needle electroacupuncture treatment was applied, and the acupuncture points were as follows: bilateral Zusanli (ST36), Neiguan (PC6), Hegu (LI4), Shaoshang (LU11), and Feng Long (ST40). 1 time a day, 30 minutes each time, for 7 days. 2. Control group: Placebo needles were applied, and the acupuncture points were as follows: bilateral Zusanli (ST36), Neiguan (PC6), Hegu (LI4), Shaoshang (LU11), and Feng Long (ST40). 1 time a day, 30 minutes each time, for 7 days.
Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine
Nanjing, Jiangsu, China
Respiratory mechanics indicators 1
Oxygenation index(P/F)
Time frame: Day 0、day 7
Respiratory mechanics indicators 2
Respiratory rate(RR)
Time frame: Day 0、day 7
Respiratory mechanics indicators 3
Driving pressure(DP)
Time frame: Day 0、day 7
Respiratory mechanics indicators 4
Positive end expiratory pressure(PEEP)
Time frame: Day 0、day 7
Respiratory mechanics indicators 5
Mechanical ventilation days(MV days)
Time frame: Day 0、day 7
Respiratory mechanics indicators 6
Mechanical ventilation free days(MV free days)
Time frame: Day 0、day 7
Respiratory mechanics indicators 7
Extubation situation
Time frame: Day 0、day 7
Sedation and analgesia
RASS score
Time frame: Day 0、day 7
Sedative drug use
The dose and duration of sedative medication will be recorded.
Time frame: Day 0、day 7
Analgesic drug use
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
The dose and duration of analgesic medication will be recorded.
Time frame: Day 0、day 7
Inflammatory factors
IL-1β、IL-6、IL-2、IL-4、IL-5、IL-8、IL-10、IL-17、IL-12、 IFN-γ、IFN-α、TNF-α.
Time frame: Day 0、day 7
CD4、CD8、CD4/CD8
Flow cytometry will be used to detect serum CD4, CD8 and CD4/CD8 levels.
Time frame: Day 0、day 7
Vasoactive drugs applications
The duration of vasoactive drug use will be recorded.
Time frame: Day 0 to day 7
CRRT applications
The duration of continuous renal replacement therapy will be recorded.
Time frame: Day 0 to day 7
ECMO applications
The duration of extracorporeal membrane oxygenation will be recorded.
Time frame: Day 0 to day 7
All-cause mortality to day 28
The prognosis of patients on the 28th days will be counted.
Time frame: Up to 28 days
All-cause mortality to day 60
The prognosis of patients on the 60th days will be counted.
Time frame: Up to 60 days
ICU-free days
The prognosis of patients ICU length of stay will be counted.
Time frame: 2 year
Hospital-free days
The prognosis of patients total length of stay will be counted.
Time frame: 2 year