The goal of this clinical trial is to compare physician-guided (SOC) versus nurse-led natriuresis-guided diuretic therapy in patients with acute decompensated heart failure (ADHF). The main questions it aims to answer are: * difference in natriuresis and diuresis * feasibility of the protocol. Participants will be asked to gather two 24 h urine collections. Researchers will compare SOC versus nurse-led diuretic titration to see if there is a difference in natriuresis after 48 hours.
The EASY-HF study was a single-centre, randomized, open-label study comparing standard of care (SOC) diuretic management at the treating physician's discretion with a nurse-led natriuresis-guided protocol in patients with ADHF. A bedside sensor was used to measure the urinary sodium content.The primary endpoint was total natriuresis after 48 hours. Secondary endpoints included safety profile and user-friendliness of both the protocol and the point-of-care sensor.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
60
Nurse-led natriuresis-guided protocol based on a bedside urinary sodium result
Diuretic therapy at the discretion of the physician
Ziekenhuis Oost-Limburg AV
Genk, Limburg, Belgium
Urinary sodium excretion after 48 hours
Total natriuresis after 48 hours (mmol)
Time frame: 48 hours
Urinary output after 48 hours
Total diuresis after 48 hours (ml)
Time frame: 48 hours
Urinary sodium excretion on daily base
Total natriuresis (mmol) during the first and second 24 h
Time frame: 24 hours
Urinary output on daily base
Total diuresis during the first and second 24 h
Time frame: 24 hours
Achievement of decongestion
Congestion score of no more than trace edema (score \< 2) after 48 hours of diuretic treatment. Minimum score 0 (decongested), maximum score 10 (severe congested)
Time frame: 48 hours
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