The longitudinal observational study aims to assess the impact of the microbiome especially the gut-microbiome in the emergence and course of giant cell arteritis (abbr. GCA) patients. At diagnosis and 6 month follow up we will analyze the oral, blood and gut microbiome from GCA patients and healthy controls. Thereby identified potential candidate biota will be further analyzed for possible interactions and influence on the immune system.
Study Type
OBSERVATIONAL
Enrollment
50
Analysis of blood and microbiome samples (stool, oral lavage) especially composition of the gut microbiome and potential interaction with immune cells
Clinic of Internal Medicine III, Department of Oncology, Haematology, Rheumatology and Clinical Immunology, University Hospital Bonn
Bonn, North Rhine-Westphalia, Germany
RECRUITINGUniversity Hospital Bonn
Bonn, Germany
RECRUITINGSignificant differences in the composition of the microbiome
Time frame: At Baseline and 6 month follow up
Influence of the microbiome on therapy response e.g. increased probability of recurrence with accumulation of specific microbiome species
Time frame: At Baseline and 2 year follow up
potential association of microbiome composition with application of immune modulating drugs
Time frame: At Baseline and 6 month follow up
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