Postoperative pain management is essential and the inability to treat acute pain appropriately in the first 48 postoperative hours represents a risk factor for developing chronic pain. No. study has investigated IP granisetron as an adjuvant to standard care for postoperative pain management in patients undergoing LC.
Postoperative pain is a main challenge for delayed hospital discharge in Laparoscopic cholecystectomy. . Postoperative pain management is essential and the inability to treat acute pain appropriately in the first 48 postoperative hours represents a risk factor for developing chronic pain. Granisetron is frequently used as a premedication to avoid postoperative nausea and vomiting in patients who have undergone general anesthesia. The purpose of this study is evaluating the efficacy and tolerability of IP granisetron on postoperative pain control in patients undergoing LC
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
46
2mL intraperitoneal adminstration of granisetron (1 mg/mL)
2 ml IP normal saline (0.9% NaCl)
National Hepatology and Tropical Research Institute
Cairo, Egypt
VAS score
Pain intensity: VAS score
Time frame: 2 hours, 4 hours, 8 hours, 12 hours, 24 hours
Time to analgesic request
Time to first rescue analgesic request
Time frame: 24 hours
Quality of life (QoL) after laparoscopic cholecystectomy (LC)
Gastrointestinal Quality of Life Index questionnaire for QOL assessment with calculation of the score; most desirable option: 4 points, least desirable option: 0 points and GIQLI score: sum of the point. GIQLI ranges from 0 to 80 with higher scores indicating a better quality of life.
Time frame: 3 months
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