FeelFit: High-intensity Interval Training to Improve Self-reported Physical Fitness in Brain Tumor Patients

Amsterdam UMC, location VUmc36 enrolled

Overview

The FeelFit study aims to assess the effectiveness of High-Intensity Interval Training (HIIT) in improving self-reported physical fitness in adult brain tumor patients during periods of stable disease, as compared to a waiting-list control group. Furthermore, several secondary and exploratory outcomes will be evaluated. The study is part of the GRIP (GuaRding quality survivorshiP) project, which aims to improve quality of life in brain tumor patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Brain Tumor, Primary Exercise

Interventions

Individualized High-Intensity Interval Training (HIIT) program with two exercise sessions per week for 12 weeks. The exercise sessions will be conducted on a stationary bike, with intensity tailored to each participant's maximum exercise capacity.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * reduced self-reported physical fitness; * minimum age of 18 years; * diagnosed with a primary brain tumor; * stable disease, i.e. no signs of radiological or clinical tumor progression; * no oncological treatment for at least two months prior to inclusion; * able to speak, read and write in Dutch. Exclusion Criteria: * Karnofsky Performance Score \< 70; * already participated in a HIIT program \< 1 month prior; * contraindication of exercise.

Outcomes

Primary Outcomes

Self-reported physical fitness

Self-reported physical fitness is measured using the first question of the International Fitness Scale (IFIS) on general physical fitness, on a 5-point scale where a higher score corresponds to better self-reported physical fitness.

Time frame: Baseline versus post-intervention (12 weeks) and versus follow-up (12 weeks and 6 weeks follow-up)

Secondary Outcomes

Self-reported fitness

In addition to the first question of the International Fitness Scale (IFIS), the other questions about cardiorespiratory fitness, muscle strength, speed and flexibility will also be asked as secondary outcomes.

Time frame: Baseline versus post-intervention (12 weeks) and versus follow-up (12 weeks and 6 weeks follow-up)

VO2max

Physical fitness defined as the maximal oxygen uptake measured with a cardiopulmonary exercise test.

Time frame: Baseline versus post-intervention (12 weeks)