The goal of this observational study is to learn about the eravacycline combination therapy in multidrug-resistant acinetobacter gaumannii pneumonia. The main question is to evaluate the the effectiveness and safety. Participants will be given Eravacycline and Polymyxin,or other antibiotcs that the Investigator considered suitable. During the clinical trial, participants will be monitored for blood drug concentrations and drug concentrations in the ELF (Epithelial Lining Fluid。Clinical efficacy rate and microbiological clearance rate will be assessed at the same time
Study Type
OBSERVATIONAL
Enrollment
20
Eravacycline at the recommended dose and administration method according to the instructions: 1 mg/kg intravenous administration, every 12 hours. The intravenous infusion duration is approximately 60 minutes. For patients with severe liver impairment (Child-Pugh class C), administer 1 mg/kg of this product every 12 hours on the first day, followed by 1 mg/kg every 24 hours starting from the second day.
Fujian Medical University Union hospital
Fuzhou, Fujian, China
RECRUITINGClinical Responded Rate
Complete the treatment, and meet one of the following criteria to be considered clinical respond: 1. Patient's oxygenation index is stable or improved; 2. Patients with a SOFA score \<3 remain unchanged or decrease, and patients with a SOFA score ≥3 decrease by at least 30%; 3. Normal body temperature for more than 3 days; 4. Improvement in pulmonary imaging; 5. Infection indicators show a continuous downward trend for 3 consecutive day
Time frame: 28 days
The microbiological clearance rate
The microbiological clearance rate at the end of treatment
Time frame: within 14days
The all-cause mortality rate within 28 days
The all-cause mortality rate within 28 days
Time frame: 28 days
"Incidence Rate of Adverse Event
safety data according to CTC-AE
Time frame: 28days
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.