Measuring Various Variables in Obstructive Sleep Apnea

Cumhuriyet University90 enrolled

Overview

This study included 90 volunteer Obstructive Sleep Apnea Syndrome patients. Only 7 mL blood samples collected from patients. Some biochemicals parameters analyzed in blood serum/plasma.

This study included 90 volunteer patients diagnosed with OSAS, and they were divided into three groups according to the apnea-hypopnea index (AHI) score: mild OSAS (n=30;5≤ AHI ≤13.70), moderate (n=30;15.80≤AHI≤26.60) and severe (n=30;34.10≤AHI≤86.30). Demographic data, as well as biochemical parameters, nocturnal oxygen saturation percentage (SpO2), and body mass index (BMI) were measured. Plasma agmatine levels were measured by ultra-high-pressure liquid chromatography (UHPLC), plasma trace elements (Cu, Co, Mg, Mo, Zn, Se) levels were determind by inductively coupled plasma mass spectrometer (ICP-MS) and serum telomerase levels were measured by enzyme-linked immunosorbent assay (ELISA) method. Analyzes were carried out at the Cumhuriyet University advanced technology research and application center.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

TRIPLE

Enrollment

Conditions

Obstructive Sleep Apnea-hypopnea Syndrome

Interventions

taking a blood sampleDIAGNOSTIC_TEST

Blood samples collected from patienst, only 7 mL

Eligibility

Sex: ALLMin age: 18 YearsMax age: 74 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of obstructive sleep apnea disease * Apnea-hypopnea index (AHI) score between 5-87 Exclusion Criteria: * asthma * chronic obstructive pulmonary disease * pneumonia * psychiatric * diabetes * heart failure * who work at night work

Locations (1)

Sivas Cumhuriyet University

Sivas, Centre, Turkey (Türkiye)

Outcomes

Primary Outcomes

Agmatine, telomerase and trace element levels in blood serum vary depending on disease severity.

Agmatine Telomerase and trace element levels will be measured in blood serum. The most common side effect when blood is taken from the patient is slight bruising and swelling in the arm due to needle sticking. There will be no other serious side effects.

Time frame: not measured in time frame. general (one day)

Secondary Outcomes

Polysomnographic measurement

Patients will be put to sleep for 1 night with polysomnography, and the severity of the disease will be determined by calculating the number of times breathing stops during sleep with the Apnea-hypoapnea index. There will be no side effects.

Time frame: one day

Data from ClinicalTrials.gov

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