Sedatives and analgesics are usually given for analgesic, anxiolytic, or sedating purposes for patients with critical illness, while they inevitably inhibit respiratory and circulatory function. Sometimes, patients receive deep sedation to induce hypoventilation or suppress spontaneous respiratory effort. The sedation level in clinical practice is usually assessed with subjective sedation scoring systems, such as the Richmond Agitation Sedation Scale (RASS). However, studies have found that sedation depth based on RASS is not a reliable marker of respiratory drive during critical illness. In recent years, researchers have proposed to monitor the effects of sedatives and analgesics on respiratory indicators and to implement lung-protective sedation, such as P0.1, Pocc, Pmus, WOB, and PTP. However, different pharmacological characteristics, different depths of sedation, and different sedation regimens among different sedatives and analgesics make a great difference in their effects on respiration. Ciprofol is an analog of propofol, with increased stereoselective effects adding to its anesthetic properties, is increasingly used in the intensive care unit, but its effects on respiration are not well understood. Therefore, this study aims to investigate the effects of ciprofol on respiratory patterns, respiratory drive, and inspiratory effort in mechanically ventilated patients.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
20
Ciprofol will be infused at 0.3，0.4，0.5，0.6，0.7，0.8 mg/kg/h in sequence for 30 minutes at each dose.
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China
RECRUITINGExplore the effect of ciprofol on tidal volume
Change from baseline in tidal volume (ml) at 30 minutes after infusion of ciprofol
Time frame: At baseline (before sedation with ciprofol) and 0.3 mg/kg/h ciprofol continuous infusion for 30 minutes
Explore the effect of ciprofol on respiratory rate
Change from baseline in respiratory rate (breaths/min) at 30 minutes after infusion of ciprofol
Time frame: At baseline (before sedation with ciprofol) and 0.3 mg/kg/h ciprofol continuous infusion for 30 minutes
Explore the effect of ciprofol on minute ventilation
Change from baseline in minute ventilation (L/min) at 30 minutes after infusion of ciprofol
Time frame: At baseline (before sedation with ciprofol) and 0.3 mg/kg/h ciprofol continuous infusion for 30 minutes
Explore the effect of ciprofol on P0.1
Change from baseline in P0.1 (cmH2O) at 30 minutes after infusion of ciprofol
Time frame: At baseline (before sedation with ciprofol) and 0.3 mg/kg/h ciprofol continuous infusion for 30 minutes
Explore the effect of ciprofol on PMI
Change from baseline in PMI (cmH2O) at 30 minutes after infusion of ciprofol
Time frame: At baseline (before sedation with ciprofol) and 0.3 mg/kg/h ciprofol continuous infusion for 30 minutes
Explore the effect of ciprofol on ΔPocc
Change from baseline in ΔPocc (cmH2O) at 30 minutes after infusion of ciprofol
Time frame: At baseline (before sedation with ciprofol) and 0.3 mg/kg/h ciprofol continuous infusion for 30 minutes
Explore the effect of ciprofol on tidal volume
Change from baseline in tidal volume (ml) at 30 minutes after infusion of ciprofol at different rates
Time frame: At baseline (before sedation with ciprofol) and 30 minutes following each infusion rate adjustment (0.4，0.5，0.6，0.7，0.8 mg/kg/h)
Explore the effect of ciprofol on respiratory rate
Change from baseline in respiratory rate (breaths/min) at 30 minutes after infusion of ciprofol at different rates
Time frame: At baseline (before sedation with ciprofol) and 30 minutes following each infusion rate adjustment (0.4，0.5，0.6，0.7，0.8 mg/kg/h)
Explore the effect of ciprofol on minute ventilation
Change from baseline in minute ventilation (L/min) at 30 minutes after infusion of ciprofol at different infusion rates
Time frame: At baseline (before sedation with ciprofol) and 30 minutes following each infusion rate adjustment (0.4，0.5，0.6，0.7，0.8 mg/kg/h)
Explore the effect of ciprofol on P0.1
Change from baseline in P0.1 (cmH2O) at 30 minutes after infusion of ciprofol at different rates
Time frame: At baseline (before sedation with ciprofol) and 30 minutes following each infusion rate adjustment (0.4，0.5，0.6，0.7，0.8 mg/kg/h)
Explore the effect of ciprofol on PMI
Change from baseline in PMI (cmH2O) at 30 minutes after infusion of ciprofol at different rates
Time frame: At baseline (before sedation with ciprofol) and 30 minutes following each infusion rate adjustment (0.4，0.5，0.6，0.7，0.8 mg/kg/h)
Explore the effect of ciprofol on ΔPocc
Change from baseline in ΔPocc (cmH2O) at 30 minutes after infusion of ciprofol at different rates
Time frame: At baseline (before sedation with ciprofol) and 30 minutes following each infusion rate adjustment (0.4，0.5，0.6，0.7，0.8 mg/kg/h)
Explore the effect of ciprofol on systolic blood pressure
Change from baseline in systolic blood pressure (mmHg) at 30 minutes after infusion of ciprofol at different rates
Time frame: At baseline (before sedation with ciprofol) and 30 minutes following each infusion rate adjustment (0.3，0.4，0.5，0.6，0.7，0.8 mg/kg/h)
Explore the effect of ciprofol on diastolic blood pressure
Change from baseline in diastolic pressure (mmHg) at 30 minutes after infusion of ciprofol at different rates
Time frame: At baseline (before sedation with ciprofol) and 30 minutes following each infusion rate adjustment (0.3，0.4，0.5，0.6，0.7，0.8 mg/kg/h)
Explore the effect of ciprofol on mean arterial pressure
Change from baseline in mean arterial pressure (mmHg) at 30 minutes after infusion of ciprofol at different rates
Time frame: At baseline (before sedation with ciprofol) and 30 minutes following each infusion rate adjustment (0.3，0.4，0.5，0.6，0.7，0.8 mg/kg/h)
Explore the effect of ciprofol on heart rate
Change from baseline in heart rate (beats/min) at 30 minutes after infusion of ciprofol at different rates
Time frame: At baseline (before sedation with ciprofol) and 30 minutes following each infusion rate adjustment (0.3，0.4，0.5，0.6，0.7，0.8 mg/kg/h)
Explore the effect of ciprofol on saturation of pulse oxygen
Change from baseline in saturation of pulse oxygen (%) at 30 minutes after infusion of ciprofol at different rates
Time frame: At baseline (before sedation with ciprofol) and 30 minutes following each infusion rate adjustment (0.3，0.4，0.5，0.6，0.7，0.8 mg/kg/h)
Explore the effect of ciprofol on end-tidal carbon dioxide pressure
Change from baseline in end-tidal carbon dioxide pressure (mmHg) at 30 minutes after infusion of ciprofol at different rates
Time frame: At baseline (before sedation with ciprofol) and 30 minutes following each infusion rate adjustment (0.3，0.4，0.5，0.6，0.7，0.8 mg/kg/h)
Explore the effect of ciprofol on RASS score
Change from baseline in RASS score at 30 minutes after infusion of ciprofol at different rates
Time frame: At baseline (before sedation with ciprofol) and 30 minutes following each infusion rate adjustment (0.3，0.4，0.5，0.6，0.7，0.8 mg/kg/h)
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