Alveolar-capillary Reserve After Exercise in Chronic Obstructive Pulmonary Disease (COPD) (COP-DTPA)

Rigshospitalet, Denmark32 enrolled

Overview

It is unknown whether individuals with COPD exhibit abnormal alveolar-capillary breaching during exercise, and whether this contributes to exertional dyspnoea. The aim of this study is to investigate whether individuals with COPD exhibit an abnormal increase in alveolar-capillary breaching during exertion, as indicated by an increase alveolar-capillary permeability with a concomitantly exacerbated increase in lung tissue mass. The study participants include a control group and a group with COPD (GOLD I-III). Participants are undergoing three study days: (1) Measurement of maximal aerobic capacity and lung function test, (2) lung tissue mass and alveolar-capillary permeability is measured at rest and again 2 hours later, immediately after the participant has exercised on a bicycle ergometer and (3) supine cardiac output and pulmonary capillary blood volume will be measured at rest and immediately after exercise.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Chronic Obstructive Pulmonary Disease

Interventions

Acute exercise bout on visit 2 and 3OTHER

1\) a 5-minute warm-up, 2) 4 minutes at 60% of the maximal workload (determined on Study Day 1), 3) 2 minutes active break at 15 watt, 4) 4 minutes at maximal workload.

Eligibility

Sex: ALLMin age: 45 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria - individuals with COPD * Men and women * 45-80 years old * COPD (GOLD stage I to III) * Resting arterial oxygenation \> 90% Inclusion criteria - healthy controls * Men and women * 45-80 years old * Non-smokers * Normal lung function * Same sex, age (± 3 years) as the COPD group Exclusion criteria - individuals with COPD * Symptoms of ischemic heart disease * Known heart failure * Symptoms of illness, including fever, within 2 weeks prior to the study * Pregnancy * • Known renal or liver diseaseActive smoking (within 3 weeks) Exclusion criteria - healthy controls * Known chronic lung disease * Symptoms of ischemic heart disease * Known heart failure * Symptoms of illness, including fever, within 2 weeks prior to the study * Pregnancy * Known renal or liver disease * Active smoking (within 3 weeks)

Locations (1)

Center For Physical Activity Research, Rigshospitalet

Copenhagen, Denmark

Outcomes

Primary Outcomes

Rest-to-exercise pulmonary DTPA clearance change after exercise in COPD vs. controls

The physiological change from rest to exercise in DTPA clearance

Time frame: Measured at study day 2

Secondary Outcomes

Pulmonary DTPA clearance at rest in COPD vs. controls

Pulmonary DTPA clearance measured by pulmonary DTPA clearance at rest

Time frame: Measured at study day 2

Pulmonary DTPA clearance after exercise in COPD vs. controls

Pulmonary DTPA clearance measured by pulmonary DTPA clearance after exercise

Time frame: Measured at study day 2

Rest-to-exercise change in lung tissue mass in COPD vs. controls

The physiological change from rest to exercise in lung tissue mass measured by low-dose CT-scan

Time frame: Measured at study day 2

Data from ClinicalTrials.gov

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