Efficacy of Structured Exercise-Nutritional Intervention on Sarcopenia in Patients With Osteoporosis

Inclusion Criteria: 1. Diagnosis of sarcopenia: * Low hand grip strength (Male: \<28 kg, Female: \<18 kg) AND * Low appendicular skeletal mass by bioimpedance analysis (Male: \<7.0 kg/m2 Female: \<5.7 kg/m2) 2. Diagnosed with osteoporosis by: * Fragility fracture or * T-score ≤-2.5 SDs at any site based upon BMD measurement by Dual Energy X-ray Absorptiometry (DXA) scan Exclusion Criteria: 1. Incompetent in giving consent or following commands 2. Non-ambulatory subject 3. Unstable medical conditions contributing to sarcopenia, for example but not limited to: 1. End stage organ failure 2. Unstable cardiovascular, respiratory, gastrointestinal and endocrine conditions 3. Active malignancy 4. Chronic kidney disease stage IV or above or with hyperkalaemia 5. Diabetes mellitus on medications or with unstable control 6. Terminal illness 7. Obese subjects (BMI ≥ 25.0) 8. Self-reported allergy to the ingredients of the nutrition supplement 9. Patients with metallic implants 10. Any orthopaedic pathologies affecting the strength of bilateral upper limbs 11. Any hereditary or acquired muscular diseases 12. Participation in other regular exercise programme