Function and Morphological Characteristics of Meibomian Gland in Patients With Renal Anemia

Zhongnan Hospital50 enrolled

Overview

Renal anemia refers to anemia in which the absolute or relative production of erythropoietin (EPO) is insufficient due to various kidney diseases, and uremic toxins affect erythropoietin production and its lifespan. Common treatment drugs for renal anemia include erythropoietin EPO and Roxadustat (FG-4592). Medical history information was collected from patients with renal anemia who visited the ophthalmology department with dry eye symptoms. This study will help to determine the function and morphological characteristics of meibomian gland in patients with renal anemia

1. Collect medical records of patients with renal anemia who visited the ophthalmology outpatient department of Zhongnan Hospital and hospitalized patients with renal anemia 2. Patients were divided into Rosallistat group, and EPO group according to their drug use history. 3. The dry eye analysis results of all patients were collected, and the lacrimal river height, tear film rupture time and meibomian gland grade were counted. The results of dry eye examination were analyzed statistically. 4. Complete data collection, conduct statistical analysis, and evaluate the analysis results.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Dry Eye MGD-Meibomian Gland Dysfunction

Interventions

Dry eye examinationDIAGNOSTIC_TEST

1. Lacrimal river height 2. tear break-up time 3. tear-film lipid layer thickness 4. meibomian glands two-dimensional digital infrared images

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * long-term use of Roxadustat or erythropoietin for renal anemia Exclusion Criteria: * contact lens wearer, history of eye surgeries, systemic health conditions affecting ocular health and those who were unable to cooperate with examinations

Locations (1)

Zhongnan Hospital of Wuhan University

Wuhan, Hubei, China

RECRUITING

Outcomes

Primary Outcomes

Lacrimal river height

Measured by dry eye analyzer machine

Time frame: Immediately and six months later

tear break-up time

Measured by dry eye analyzer machine

Time frame: Immediately and six months later

tear-film lipid layer thickness

Measured by dry eye analyzer machine

Time frame: Immediately and six months later

meibomian glands two-dimensional digital infrared images

Measured by dry eye analyzer

Time frame: Immediately and six months later

Data from ClinicalTrials.gov

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