Efficacy of Olanzapine on Weight Gain in Advanced Gynecologic Cancer with Paclitaxel and Carboplatin: a Double Blind, Placebo-controlled Randomized Trial

Department of Medical Services Ministry of Public Health of Thailand48 enrolled

Overview

* Efficacy of olanzapine on weight gain in advanced stage gynecologic cancer * Proprotion of pateints in advanced stage gynecologic cancer who recieving paclitaxel and carboplatin chemotherapy gain weight on olanzapine or placebo

-Proprotion of pateints in advanced stage gynecologic cancer who recieving paclitaxel and carboplatin chemotherapy gain weight on olanzapine or placebo

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Weight Gain

Interventions

weight gain each groupOTHER

weight gain after 12 Weeks

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Advanced stage gynecologic cancer receiving Paclitaxel and carboplatin chemotherapy * ECOG 0-1 * Normal CBC,Liver, renal function * Communication in Thai language or Thai caregiver * Inform consent Exclusion Criteria: * Pregnancy * Active infection * Bowel obstruction or history of bowel surgery * On dopamine receptor antagonists or psychiatric or anticonvulsant medication * Olanzapine allery * Abnormal function of liver and renal * Diabetic melitus or morbid obesity * patient can't selfcare

Locations (1)

Rajavithi Hospital

Bangkok, Thailand

RECRUITING

Outcomes

Primary Outcomes

Efficacy of olanzapine on weight gain in advanzed stage gynecologic cancer recieving paclitexal and carboplatin chemotherapy

proprotion of pateints gain weight after intervention (olanzapine or placebo) by monitor weight before and after get intervention

Time frame: 12 weeks after intervention

Data from ClinicalTrials.gov

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