Introduction: One of the consequences of aging is the decrease in physical performance which can affect the quality of life of older people. Although physical exercise is beneficial in improving this problem, older women do not seem to benefit as much as men. In this sense, the use of ergonomic aids by women could compensate for these issues. Thus, green tea has shown beneficial effects on physical performance in athletes through, among others, improving blood flow and vasodilation, mitochondrial respiration, calcium management, glucose and amino acid uptake, lipid oxidation, modulation of muscle damage, antioxidant effect, and anabolic and catabolic hormones, activation of the hypothalamic-pituitary-adrenal axis, etc. Therefore, the deterioration of physical performance and quality of life of green tea. Objective: To analyze the effect of supplementation with 1 g/day green tea extract (500 mg of polyphenols) for 10 weeks on quality of life values, physical performance (grip strength, walking speed, and resistance), and health biomarkers (biochemical, hematological, and hormonal) in women over 60 years of age who follow a physical training program. Methods: A total of 20 female volunteers between 60 and 73 years old (age: 65.9±4.58 years, BMI: 25.09±3.24 and body fat percentage: 32.54±6.39) who followed a physical activity adapted to their age and abilities are the members of this study. The volunteers were divided into two groups: placebo (CG; n = 10) and supplemented with 1 g/day of green tea (GI; n = 10). Different physical tests were performed (grip strength, walking speed and resistance) and the quality of life questionnaire (WHOQOL-BREF) was passed and health biomarkers (biochemical, hematological, and hormonal) were analyzed at the beginning (T1) and at the end of the 10 weeks of intervention (T2).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
120
Two capsules per day; Each capsule includes Green Tea Leaf (Camellia sinensis) 5000 mg composed of 500 mg of green tea extract and 250 mg of polyphenols (epicatechin (EC), epigallocatechin (EGC), epicatechin gallato (ECG), and epigallocatechin gallato (EGCG))
Two capsules per day; Each capsule includes 100-mg maltodextrin capsules were used as a placebo to match the color and texture of the Green tea tablets to ensure blinding.
Faculty of Health Sciences, University of Valladolid Soria Campus
Soria, Spain
RECRUITINGCreatine kinase (CK)
CK is an enzyme expressed by various tissues and cell types; markers of muscle damage
Time frame: first day of study and after 30 days of supplementation (end of study)
Lactate dehydrogenase (LDH)
LDH is a catalytic enzyme found in many tissues of the body;markers of muscle damage
Time frame: first day of study and after 30 days of supplementation (end of study)
Myoglobin (Mb)
Mb is a muscle heteroprotein
Time frame: 1st and 30th days of the trial
Alanine Aminotransferase (ALT)
markers of liver damage
Time frame: 1st and 30th days of the trial
Aspartate Aminotransferase (AST)
markers of liver damage
Time frame: 1st and 30th days of the trial
Interleukin 6 (IL-6)
inflammatory marker
Time frame: 1st and 30th days of the trial
C-reactive protein (PCR)
inflammatory marker
Time frame: 1st and 30th days of the trial
Testosterone
hormonal marker
Time frame: 1st and 30th days of the trial
Cortisol
hormonal marker
Time frame: 1st and 30th days of the trial
Miostatin (GDF8)
growth factor that limits the growth of muscle tissue
Time frame: 1st and 30th days of the trial
advanced oxidation protein products (AOPP)
amino acid oxidation marker
Time frame: 1st and 30th days of the trial
lipid peroxidation (LPO)
lipid oxidation marker
Time frame: 1st and 30th days of the trial
Oxygen radical absorption (ORAC)
antioxidant strength marker
Time frame: 1st and 30th days of the trial
Total antioxidant status (TAS)
antioxidant capacity marker
Time frame: 1st and 30th days of the trial
Total antioxidant capacity (TAC)
antioxidant capacity marker
Time frame: 1st and 30th days of the trial
Short Physical Performance Battery (SPPB)
Test evaluates three aspects of mobility
Time frame: 1st and 30th days of the trial
World Health Organization Quality of Life - BREF (WHOQOL-BREF)
a self-report questionnaire which assesses 4 domains of quality of life (QOL): physical health, psychological health, social relationships, and environment
Time frame: 1st and 30th days of the trial
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