This project uses HER2 protein as the target group of radiodrugs to explore the diagnostic efficacy, safety and metabolic characteristics of 68Ga-Her2-affibody in the expression status of HER2, aiming to provide a new imaging method for the determination of HER2 status in breast cancer At the same time, it also provides new methods and means for early diagnosis, accurate staging, recurrence judgment, treatment decision-making and prognosis judgment of malignant tumors such as lung cancer, gastrointestinal cancer and bladder cancer, and provides scientific basis for precise treatment of malignant tumors.
This project uses HER2 protein as the target group of radiodrugs to explore the diagnostic efficacy, safety and metabolic characteristics of 68Ga-Her2-affibody in the expression status of HER2 in whole body cancer lesions, aiming to provide a new imaging method for the determination of HER2 status in breast cancer and supplement more overall information that is difficult to obtain by traditional core needle biopsy. At the same time, it also provides new methods and means for early diagnosis, accurate staging, recurrence judgment, treatment decision-making and prognosis judgment of malignant tumors such as lung cancer, gastrointestinal cancer and bladder cancer, and provides scientific basis for precise treatment of malignant tumors.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
30
68Ga-Her2-affibody is injected intravenously with a dose of 0.06-0.08 mCi/kg.
Peking University First Hospital
Beijing, Beijing Municipality, China
RECRUITINGThe diagnostic efficacy of 68Ga-Her2-affibody PET/CT in the evaluation of breast cancer
the standardized Uptake Value (SUV) of lesions on 68Ga-Her2-affibody PET/CT
Time frame: 1 year
The dosimetry of 68Ga-Her2-affibody
Research on the dose distribution of 68Ga-Her2-affibody in cancer patients by 1-hour dynamic PET/CT acquisition and analyze by the dosimetry software
Time frame: 1 year
Quantitative evaluation of 68Ga-Her2-affibody
Analyze Her2 expression at the imaging level in combination with Her2 expression
Time frame: 1 year
Correlation with pathological expression
Analyze Her2 expression at the imaging level in combination with Her2 expression in pathological specimens
Time frame: 1 year
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