The current preoperative fasting guidelines recommend, applying preoperative carbohydrate solution 2 hours before the operation to minimize prolonged fasting time potential negative effects and improve patient comfort. Fasting after midnight before the operation day is a widespread practice. The major obstacle to preoperative carbohydrate solutions becoming prevalent and extremely long fasting time is the limited product; which is proven safe and efficient, and unavailable in several countries. In this study, our objective is to analyze the gastric volume, preoperative anxiety, stress response, postoperative insulin resistance, and postoperative nausea and vomiting by utilizing a low osmolality oral carbohydrate solution prepared with ginger and melissa.
The current preoperative fasting guidelines recommend, applying preoperative carbohydrate solution 2 hours before the operation to minimize prolonged fasting time potential negative effects and improve patient comfort. Fasting after midnight before the operation day is a widespread practice. The major obstacle to preoperative carbohydrate solutions becoming prevalent and extremely long fasting time is the limited product; which is proven safe and efficient, and unavailable in several countries. In this study, our objective is to analyze the gastric volume, preoperative anxiety, stress response, postoperative insulin resistance, and postoperative nausea and vomiting by utilizing a low osmolality oral carbohydrate solution prepared with ginger and melissa. 109 patients who underwent elective laparoscopic cholecystectomy, aged 18-65 years, and ASA physical state 1-2 were included in the study. The patients were divided into 3 groups: Group A, who would not eat anything 6-8 hours before the operation, Group S, who drank 400 ml of water 2 hours before the operation, and Group K, which drank 400 ml preoperative oral carbohydrate solution (PreOKH) 2 hours before the operation. Before induction of anesthesia (T1), patients' antral gastric cross-sectional area (GKA) and gastric volume (GV) were evaluated by gastric ultrasound. The preoperative anxiety level of the patients was determined by the State-Trait Anxiety Inventory (STAl) before the operation (T1), and the symptoms affecting the preoperative patient comfort parameters (thirst, hunger, dry mouth, fatigue) were measured 2 hours before the operation (T0) and before the induction (T1) evaluated with the visual analog scale (VAS). Postoperative nausea and vomiting (PONV) and postoperative pain levels were recorded. Blood glucose, insulin, and cortisol levels of the patients were measured 2 hours before the operation (T0), before induction (T1), and postoperative 2nd hour (T3)
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
120
water and solution will be given to patients to drink 2 hours before the operation
Bezmialem University
Istanbul, Fatih, Turkey (Türkiye)
RECRUITINGGastric volume
Assessment of gastric volume by ultrasound
Time frame: prior to anesthesia induction
preoperative anxiety
preoperative anxiety will be assessed with the State-Trait Anxiety Inventory
Time frame: before coming to the operating room, Scored between 20 and 80 points. A high score indicates high anxiety
postoperative nausea and vomiting
postoperative nausea and vomiting scores of the patients will be evaluated
Time frame: up to postoperative 24 hours, numeric rank score is scored between 0 and 3 points
thirst, hunger, fatigue, dry mouth
thirst, hunger, fatigue, dry mouth will be evaluated with visual analog scale
Time frame: before drink (2 hous before surgery), prior to anesthesia induction, visual analog scale is scored between 0 and 10
Postoperative Pain Score
Postoperative Pain Score will be evaluated with visual analog scale
Time frame: up to postoperative 24 hours, visual analog scale is scored between 0 and 10
postoperative insulin resistance
Blood glucose mg/dL, Insulin milli-International unit/L, Cortisol µg/dL
Time frame: glucose, insulin and cortisol will be measured 2 hours before surgery(before drink), before induction and 2 hours postoperatively
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