Impact of Hepatitis B Virus Genotype on Treatment Response in Children With Chronic Hepatitis B

Inclusion Criteria: * Children from 2 years old to under 16 years old are diagnosed with hepatitis B chronic disease AND * HBsAg or HBV DNA: positive for at least six months AND * Liver enzyme ALT: continuously increased by\> 70 for male and \> 50 for female (\> 2 x ULN) AND * The virus is proliferating: HBV DNA above 20,000 IU/mL (if HBeAg positive) OR HBV DNA above 2,000 IU/mL (if HBeAg negative) AND * A parent or legal guardian of the pediatric patient obtains consent for them to participate in research. Exclusion Criteria: * HIV and hepatitis C co-infection * Patients have other chronic liver disease (Wilson, autoimmune hepatitis) * Patients are being treated with immunosuppressive drugs * Psychomotor retardation, cerebral palsy, brain sequelae