Cannabidiol and Older Adult Cannabis Users

Subjective Motor Function

Activities-specific Balance Confidence Scale. Participants asked about confidence in completion of 16 daily tasks without losing balance or becoming unsteady. Responses are on a scale from no confidence to completely confident, with higher aggregate scores meaning higher subjective motor function.

Time frame: Baseline, 4 weeks, 8 weeks

Balance

Dynamic sway (balance) measured via an app on a standard smartphone which will be attached to the participant's waist using a Velcro strap.

Time frame: Baseline, 4 weeks, 8 weeks

Anxiety

Beck Anxiety Inventory. 21 question survey. Each question is answered from 0 (not at all) to 3 (severely), where higher scores suggest higher anxiety. Total scores are between 0-63, where anything above 36 suggest potentially concerning levels of anxiety.

Time frame: Baseline, 4 weeks, 8 weeks

Depression

Beck Depression Inventory. 21 question survey. Each question is answered from 0 (not at all) to 3 (severely), where higher scores suggest higher depression. Total scores are between 0-63, where anything above 40 suggest potentially concerning levels of depression.

Time frame: Baseline, 4 weeks, 8 weeks

Blood Cytokine Levels

Blood cytokine levels will be measured from biological samples. Includes blood levels of cytokine inflammatory markers (IL6, TNF-α, IL-β, and CRP)

Time frame: Baseline, 4 weeks, 8 weeks

Depression/Anxiety

Depression Anxiety Stress Scale - 21 Item (DASS-21). Scores are between 0 and 63, with higher scores indicating more negative emotional states.

Time frame: Baseline, 4 weeks, 8 weeks

Drug Effects

Drug Effects Questionnaire (DEQ). Six questions about drug effects with possible answers of "not at all", "somewhat", and "extremely", where higher scores indicate higher drug effects.

Time frame: 4 weeks, 8 weeks

Inhibitory Control

Flanker Inhibitory Control and Attention Task

Time frame: Baseline, 4 weeks, 8 weeks

Cognitive Function

Functional Assessment of Cognitive Function - Cognitive (FACT-Cog). Scores are transformed such that scores range from 0-132 and higher scores indicate a better quality of life/cognitive function.

Time frame: Baseline, 4 weeks, 8 weeks

Pain Intensity and Interference

Brief Pain Inventory - Short Form (BPI - SF). Measures pain levels, pain interference, and relief from medication, and includes diagrams for labeling pain.

Time frame: Baseline, 4 Weeks, 8 Weeks

Cognitive Ability

Digital Symbol Substitution Test (DSST) assesses global cognitive ability

Time frame: Baseline, 4 weeks, 8 weeks

Pain Intensity

PROMIS (Patient-Reported Outcomes Measurement Information System) Pain Intensity (7-day). Scores are between 1-5, with 1 being no pain and 5 being very severe. Assessed with 2 items as well as current pain.

Time frame: Baseline, 4 weeks, 8 weeks

Change in Condition

Patient Global Impression of Change (PGIC). 7 point scale assessing subjective changes in participant's condition.

Time frame: 4 weeks, 8 weeks

Sleep Disturbance

PROMIS (Patient-Reported Outcomes Measurement Information System) Sleep Disturbance 4a. Scores are separated between the first question (sleep quality) and the remaining 7 questions. For the first question, scores are between 1 and 5, with 1 being very poor sleep quality and 5 being very good sleep quality. The remaining 7 questions are scored individually on a scale of 1--5; for some questions, higher scores mean less disturbance, and for others, a higher score means more disturbance.

Time frame: Baseline, 4 weeks, 8 weeks

Sleep-Related Impairment

PROMIS (Patient-Reported Outcomes Measurement Information System) Sleep-Related Impairment 4a. Scores are between 4 and 20, with higher scores indicating more sleep-related impairment

Time frame: Baseline, 4 weeks, 8 weeks

Memory

Rey auditory verbal learning test assesses verbal memory.

Time frame: Baseline, 4 weeks, 8 weeks