Red Light Ptosis Proof-of-Concept

University College, London10 enrolled

Overview

This study tests a new treatment to help with droopy eyelids (ptosis) and eye movement problems (squint) in children and young people with genetically confirmed mitochondrial conditions - using red-light. We use a torch to shine a red light through the closed eyelid for 3 minutes a day. The study will run for 18 months. We believe that this treatment could help strengthen the muscle in the eyelid to make it easier to open the eyes, and could also help some children with squint.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Mitochondrial Diseases Blepharoptosis

Interventions

Near-infrared lightDEVICE

daily application of near-infrared light

Eligibility

Sex: ALLMin age: 3 YearsMax age: 18 Years

Medical Language ↔ Plain English

Inclusion: Age 3 to less than 18 years Genetically confirmed diagnosis of primary mitochondrial disease (known pathogenic mutation(s) in mitochondrial or nuclear DNA known to cause primary mitochondrial disease) Ptosis Exclusion: Genetic diagnosis not consistent with primary mitochondrial disease. No genetic diagnosis Unable to cooperate with light treatment or ophthalmological assessments.

Locations (1)

Moorfields Eye Hospital NHS Foundation Trust

London, United Kingdom

RECRUITING

Outcomes

Primary Outcomes

Palpebral fissure width

Time frame: 3 months from baseline

Central Contacts

Glen Jeffery, PhD

CONTACT

020 7608 6800 g.jeffery@ucl.ac.uk

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.