About 80% of advanced ovarian cancer patients recurred in 2-3 years. Secondary cytoreduction benefits selected patients who have high chance of complete resection. Whether secondary interval surgery can be used at recurrence is not known.
Our study aims to evaluate the complete resection rate at interval cytoreductive surgery for recurrent ovarian cancer patients, and to determine the safety and survival outcomes of this approach.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
18
Carboplatin of cisplatin for 3-6 cycles
Paclitaxel, gemcitabine or liposomal doxorubicin, for 3-6 cycles
Optional
The University of Hong Kong
Hong Kong, Hong Kong
RECRUITINGComplete resection rate
Rate of complete resection at the time of operation
Time frame: 12 months
12-month progression-free survival rate
The time from the first dose of chemotherapy to the first documentation of objective tumor progression (PD) or to death due to any cause, whichever occurs first.
Time frame: 12 months
12-month overall survival rate
Overall survival is defined as the time from the first dose of chemotherapy to the date of death due to any cause.
Time frame: 12 months
Surgical complication rate
Complications are graded by the Clavien-Dindo classification
Time frame: 12 months
Quality of life scale
Different functional scales will be assessed by questionnaires like the EORTC questionnaires where all scales range from 0-100. The higher the score, the greater the intensity of that particular item is.
Time frame: 12 months
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Cytoreductive surgery after chemotherapy