This study is a retrospective study trying to find the predictive factors for medullary thyroid aggressiveness in terms of tumor metastasis and patients' survival.
This study is a retrospective study trying to find the predictive factors for medullary thyroid aggressiveness in terms of tumor metastasis and patients' survival. The predictive factors included in this study are central and lateral compartment lymph node metastases as well as distant metastasis up to 1 year postoperatively, while biochemical predictors (meaning ratios such as lymphocyte to monocyte ratio etc and CEA and calcitonin drop levels) and histological predictors (such as nuclear atypia, amyloid, immunohistochemistry, desmoplasia) are included as secondary outcomes. In this study , patients \>18 years old that underwent surgery for medullary thyroid cancer (total thyroidectomy, completion thyroidectomy) +/- central/lateral neck dissection) will be enrolled.
Study Type
OBSERVATIONAL
Enrollment
500
Total thyroidectomy
Central lymph node metastasis
Central neck compartment lymph node metastasis
Time frame: Number of lymph node Metastasis found in preoperative imaging studies or up to 1 year postoperatively
Lateral lymph node metastasis
Lateral neck compartment lymph node metastasis
Time frame: Number of lymph node Metastasis found in preoperative imaging studies or up to 1 year postoperatively
Distant metastasis
Liver and lung metastasis
Time frame: Number of distant Metastasis found in preoperative imaging studies or up to 1 year postoperatively
Nuclear atypia as histological predictor of aggressiveness
nuclear atypia
Time frame: The pathology report is held immediately after surgery
Amyloid as histological predictor of aggressiveness
amyloid
Time frame: The pathology report is held immediately after surgery
Immunohistochemistry as histological predictor of aggressiveness
immunohistochemistry
Time frame: The pathology report is held immediately after surgery
Desmoplasia as histological predictor of aggressiveness
desmoplasia
Time frame: The pathology report is held immediately after surgery
CEA as Biochemical predictor of aggressiveness
Carcinoembryonic antigen (CEA) preoperatively and up to 1 year postoperatively
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Oregon Health & Science University, Oregon
Oregon City, Oregon, United States
Department of Surgery, Saint John of God Hospital, Salzburg, Austria
Salzburg, Austria
Saint Luc, University Clouvain, Belgium
Brussels, Belgium
Head and Neck Surgery Department, Hospital Ana Nery, Santa Cruz do Sul, Brazil
Santa Cruz do Sul, Brazil
University Clinic of Surgery, University Hospital "Lozenec"
Sofia, Bulgaria
Chinese University of Hong Kong
Hong Kong, China
Head and Neck Department Oncologos del Occidente, Universidad de Caldas, Manizales, Colombia
Manizales, Colombia
the University Hospital Center Sestre milosrdnice, Zagreb, Croatia, Department of Otorhinolaryngology and Head and Neck Surgery
Zagreb, Croatia
Head and Neck Surgery, Brest University Hospital, Brest, France
Brest, France
The University Hospital of Poitiers, France
Poitiers, France
...and 36 more locations
Time frame: pre and postoperative laboratory exams up to 1 year postoperatively
Calcitonin as Biochemical predictor of aggressiveness
calcitonin levels preoperatively and up to 1 year postoperatively
Time frame: pre and postoperative laboratory exams up to 1 year postoperatively
White blood cell as Biochemical predictor of aggressiveness
white blood cell count
Time frame: pre and postoperative laboratory exams up to 1 year postoperatively
Platelet count as Biochemical predictor of aggressiveness
platelet count
Time frame: pre and postoperative laboratory exams up to 1 year postoperatively
CEA drop as Biochemical cure marker
CEA drop levels
Time frame: up to 1 year postoperatively
Calcitonin drop as Biochemical cure marker
calcitonin drop levels
Time frame: up to 1 year postoperatively