Immediate Post-Operative Anesthesia With Either Lidocaine or Bupivacaine

Early Phase 1CompletedNCT06293807

The University of Texas Health Science Center at San Antonio72 enrolled

Overview

Immediate post-suturing administration of either one of two dental anesthetic solutions or a placebo prior to dismissal.

This study seeks to evaluate the pain response following the administration of two anesthetic solutions just prior to patient dismissal from a surgical procedure: 2% Xylocaine with 1:100,000 epi and 0.5% Bupivicaine with 1:200,000 epi in comparison with 0.9% Normal Saline as a placebo. the study team will monitor pain response following these interventions at 4, 8, 12, 24, and 48 hours.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Periodontal Diseases

Interventions

Xylocaine 2 % with 1:100,000 epinephrineDRUG

Local anesthetic used during dental procedures

Bupivicaine 0.5% with 1:200,000 epinephrineDRUG

Local anesthetic used during dental procedures

PlaceboOTHER

0.9% Normal Saline solution used in place of local anesthetic

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: -Patients who have undergone a comprehensive periodontal evaluation and treatment plan not related to participation in this study and… 1. require flap surgery of 2 to 5 teeth in a continuous site (including flap debridement, flap osseous, extractions, and Guided Tissue Regeneration (GTR) procedures), and… 2. require IV sedation and local anesthesia or local anesthesia only… 3. in either the maxillary or mandibular arch. Exclusion Criteria: 1. Pregnancy, or those planning to become pregnant 2. allergy or any medical issue using Lidocaine or Bupivacaine 3. inability to take non-steroidal anti-inflammatory drugs (NSAIDS) or acetaminophen 4. non-English speaking 5. not possessing an I-phone or Android device 6. patients requiring narcotic for IV sedation 7. patients requiring either IV or oral steroids during the perioperative period

Locations (1)

The University of Texas Health Science Center at San Antonio

San Antonio, Texas, United States

Outcomes

Primary Outcomes

Change in pain using Visual Analog Scale (VAS)

Pain response recorded using a 20 point visual Analog Scale. The VAS scale is a straight line scale scored from 0-20 with 0 indicating the least amount of pain and 20 the worst pain ever experienced.