Pleurodesis Using Hypertonic Glucose

Phase 2Not Yet RecruitingNCT06293885

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's40 enrolled

Overview

Air leaks from unhealed lung tissue following lung resection for benign or malignant lesions are one of the most common complications following thoracic surgery, occurring after 10% of major lung resections. The purpose of this study is to investigate the efficacy of intrapleural administration of Dextrose 50% to resolve air leaks after pulmonary resection.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Air Leak From Lung

Interventions

Dextrose 50DRUG

a solution of 50% glucose (D50) will be injected into your pleural space

Standard of Care - No Dextrose 50OTHER

Standard of Care

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients undergoing scheduled pulmonary lobar or sublobar resection for cancer * Presence of air leak on postoperative day 1 of at least 100 mL/min, as documented on the digital drainage system Exclusion Criteria: \- None

Locations (1)

London Health Sciences Centre

London, Ontario, Canada

Outcomes

Primary Outcomes

Prolonged Air Leak

Time frame: 5 days postoperatively

Secondary Outcomes

Duration of Chest Tubes

Time frame: immediately after the surgery

Home with Chest Tube

Home with Chest Tube (y/n)

Time frame: immediately after the surgery

Central Contacts

Deb Lewis

CONTACT

519-685-8500 deb.lewis@lhsc.on.ca

Data from ClinicalTrials.gov

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