Lung Cancer Screening in HIgh Risk nonsmokErs by Artificial inteLligence Device

Inclusion Criteria: Patients are eligible to be included in the study only if all of the following criteria apply: 1. Age 50-75 years old 2. Non-smoker (defined as less than 100 cigarettes in lifetime) 3. Having a first-degree family history of lung cancer 4. Physically fit for curative treatment if early-staged lung cancer is found 5. Able to provide written informed consent 6. Consent to follow up visits and follow up CT scan if indicated 7. Consent to blood taking for translational research Exclusion Criteria: Patients who meet any of the following exclusion criteria at screening are not eligible to be enrolled in this study: 1. History of malignancy 2. Smoking history (defined as more than 100 cigarettes in lifetime) 3. Clinical symptoms suspicious for lung cancer e.g. haemoptysis, chest pain, weight loss 4. Medical comorbidities that preclude curative treatment (surgery) for lung cancer, such as severe heart disease, acute or chronic respiratory failure, home oxygen therapy, bleeding disorder 5. Pregnant ladies or ladies planning for conception 6. History of tuberculosis or interstitial lung disease 7. Pneumonia requiring antibiotic treatment within the last 12 weeks 8. CT thorax or chest performed within 2 years (including LDCT, PET-CT, MRI thorax or suspicious of lung cancer) 9. Unable or unwilling to provide written informed consent