This study will conduct 3 intervention trials with 44 different participants in each trial, with 22 participants will undergo in-laboratory overnight polysomnograms (PSGs) at one night of medication intervention, and the other 22 at taking placebo (contained starch) 1 h before sleep. Three medication regimens will be tested: (1) atomoxetine 80mg combined with oxybutynin 5mg; (2) venlafaxine 37.5mg; and (3) oxybutynin 5mg combined with trazodone 100mg. Endotypic traits will be estimated using the Phenotyping Using Polysomnography method. The primary outcome is the change in apnea-hypopnea index, and secondary outcomes include endotypic traits and sleep parameters.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
45
Atomoxetine 80mg combined with oxybutynin 5mg
Venlafaxine 37.5mg
oxybutynin 5mg combined with trazodone 100mg
Placebo tablet
China Medical University Hospital
Taichung, Taiwan
Apnea-hypopnea index
Change in apnea-hypopnea index.
Time frame: Pre-intervention and after single night intervention
Arousal threshold
Endotyping using polysomnography will be estimated with the PUP method.
Time frame: Pre-intervention and after single night intervention
Upper airway collapsibility
Endotyping using polysomnography will be estimated with the PUP method.
Time frame: Pre-intervention and after single night intervention
Loop gain
Endotyping using polysomnography will be estimated with the PUP method.
Time frame: Pre-intervention and after single night intervention
Upper airway muscle compensation
Endotyping using polysomnography will be estimated with the PUP method.
Time frame: Pre-intervention and after single night intervention
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