The purpose of this study is to evaluate how effective JNJ-77242113 is in participants with generalized pustular psoriasis (GPP) or erythrodermic psoriasis (EP).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
19
JNJ-77242113 tablet will be administered orally.
JR Sapporo Hospital
Hokkaido, Japan
Ichinomiya Municipal Hospital
Ichinomiya, Japan
Teikyo University Hospital
Itabashi Ku, Japan
Percentage of Participants With Generalized Pustular Psoriasis (GPP) Who Experienced Treatment Success at Week 16
Percentage of participants with GPP who experienced treatment success at Week 16 was reported. Treatment success for GPP was defined as at least "minimally improved" rating in Clinical Global Impression (CGI) scale for GPP based on Japanese Dermatological Association (JDA) total score. JDA severity index includes skin symptoms (area of erythema with pustules, total area of erythema, and area of edema; each scored 0-3) and systemic/laboratory findings (fever, white blood cell count, C-reactive protein, and serum albumin; each scored 0-2). JDA total score was sum of 2 assessments ranging from 0 (best) to 17 (worst). CGI ratings were defined as: 1=Very much improved (greater than or equal to \[\>=\]3-point reduction in JDA total score), 2=Much improved (1-2-point reduction), 3=Minimally improved (no change in JDA total score, but \>=20 percent (%) reduction in area of erythema with pustules or meaningful improvement in \>=1 other parameter), 4=No change, 5=Worsened. Higher score = worsening.
Time frame: Week 16
Percentage of Participants With Erythrodermic Psoriasis (EP) Who Experience Treatment Success at Week 16
Percentage of participants with EP who experienced treatment success at Week 16 was reported. Treatment success for EP was defined as at least "minimally improved" rating in CGI scale for EP. The CGI scale is a clinician-rated 5-point scale with the following categories: 1 = Very much improved, 2 = Much improved, 3 = Minimally improved, 4 = No change, 5 = Worsened. Higher score indicated worsening.
Time frame: Week 16
Percentage of Participants With GPP Who Experienced Treatment Success Over Time Based on CGI Scale According to JDA Total Score
Time frame: From baseline (Week 0) to Week 156
Percentage of Participants With EP Who Experienced Treatment Success Over Time Based on CGI Scale
Time frame: From Baseline (Week 0) to Week 156
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Hospital of the University of Occupational and Enviromental Health
Kitakyushu-shi, Japan
Kumamoto University Hospital
Kumamoto, Japan
Nagoya City University Hospital
Nagoya, Japan
Public Interest Incorporated Foundation Nipoon Life Saiseikai Nippon Life Hospital
Osaka, Japan
Tohoku University Hospital
Sendai, Japan
Dokkyo Medical University Hospital
Shimotsuga Gun, Japan
Tokyo Medical University Hospital
Shinjuku, Japan
...and 2 more locations
Change From Baseline in the Total Score of the Japanese Dermatological Association (JDA) Severity Index for GPP Over Time
Time frame: From baseline (Week 0) up to Week 156
Change From Baseline in Severity Classification of JDA Severity Index for GPP Over Time
Time frame: From baseline (Week 0) up to Week 156
Change From Baseline in the Body Surface Area (BSA) of Involvement of Lesion for EP Over Time
Time frame: From baseline (Week 0) up to Week 156
Percentage of Participants Who Achieved an Investigator's Global Assessment (IGA) Score of Cleared (0) or Minimal (1) Over Time
Time frame: Baseline (Week 0) up to Week 156
Percentage of Participants Who Achieved an IGA Score of Cleared (0) Over Time
Time frame: Baseline (Week 0) up to Week 156
Percent Improvement From Baseline in Psoriasis Area and Severity Index (PASI) Over Time
Time frame: From baseline (Week 0) up to Week 156
Change From Baseline in Dermatology Life Quality Index (DLQI) Score Over Time
Time frame: From baseline (Week 0) up to Week 156
Percentage of Participants Who Achieved DLQI Score of 0 or 1 Over Time
Time frame: Baseline (Week 0) up to Week 156
Change From Baseline in EuroQol-5 Dimension 5-Level (EQ-5D-5L) Over Time: Domain Scores
Time frame: From baseline (week 0) up to Week 156
Change From Baseline in EQ-5D-5L Over Time: Visual Analog Scale (VAS) Scores
Time frame: From baseline (Week 0) up to Week 156
Number of Participants With Treatment-emergent Adverse Events (TEAEs) and Treatment-emergent Serious Adverse Events (TESAEs)
Time frame: Baseline (Week 0) up to 160 weeks